Genetic/familial high-risk assessment: Colorectal, endometrial, and gastric, version 3.2024, NCCN Clinical Practice Guidelines In Oncology Guidelines
| Authors: | Hodan, R.; Gupta, S.; Weiss, J. M.; Axell, L.; Burke, C. A.; Chen, L. M.; Chung, D. C.; Clayback, K. M.; Felder, S.; Foda, Z.; Giardiello, F. M.; Grady, W.; Gustafson, S.; Hagemann, A.; Hall, M. J.; Hampel, H.; Idos, G.; Joseph, N.; Kassem, N.; Katona, B.; Kelly, K.; Kieber-Emmons, A.; Kupfer, S.; Lang, K.; Llor, X.; Markowitz, A. J.; Prats, M. M.; Niell-Swiller, M.; Outlaw, D.; Pirzadeh-Miller, S.; Samadder, N. J.; Shibata, D.; Stanich, P. P.; Swanson, B. J.; Szymaniak, B. M.; Welborn, J.; Wiesner, G. L.; Yurgelun, M. B.; Dwyer, M.; Darlow, S.; Diwan, Z. |
| Title: | Genetic/familial high-risk assessment: Colorectal, endometrial, and gastric, version 3.2024, NCCN Clinical Practice Guidelines In Oncology |
| Abstract: | Multigene panel testing has allowed for the detection of a growing number of inherited pathogenic/likely pathogenic variants in people at high risk of cancer, including endometrial cancer (EC). Hereditary syndromes associated with EC include Lynch syndrome, PTEN hamartoma tumor syndrome, and Peutz-Jeghers syndrome. This manuscript provides the latest recommendations from the NCCN Guidelines for Genetic/ Familial High-Risk Assessment: Colorectal, Endometrial, and Gastric on the screening and management of EC in patients at high risk for these syndromes, as well as the advantages and limitations of multigene panel testing. This manuscript also describes recent updates to these guidelines regarding de-implementation of colon cancer screening in individuals with CHEK2 pathogenic/likely pathogenic variants, based on the most up-to-date evidence regarding the association between CHEK2 pathogenic/likely pathogenic variants and colon cancer risk. © JNCCN—Journal of the National Comprehensive Cancer Network. |
| Keywords: | genetics; endometrial neoplasms; genetic predisposition to disease; practice guideline; oncology; risk assessment; colorectal neoplasms; colorectal tumor; diagnosis; medical oncology; genetic predisposition; genetic screening; stomach neoplasms; endometrium tumor; therapy; genetic testing; stomach tumor; neoplastic syndromes, hereditary; procedures; humans; human; male; female; hereditary tumor syndrome |
| Journal Title: | Journal of the National Comprehensive Cancer Network |
| Volume: | 22 |
| Issue: | 10 |
| ISSN: | 1540-1405 |
| Publisher: | Harborside Press |
| Date Published: | 2024-12-01 |
| Start Page: | 695 |
| End Page: | 711 |
| Language: | English |
| DOI: | 10.6004/jnccn.2024.0061 |
| PUBMED: | 39689429 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
