Summary of the experiences, knowledge, medical management, and family communication of monoallelic MUTYH carriers Journal Article


Authors: McKenna, D. B.; Sanchez, P.; Powers, J.; Brower, J.; Wang, L.; Mueller, R.; Symecko, H.; Hamilton, J. G.; Wildman, T.; Domchek, S. M.; Couch, F. J.; Garber, J. E.; Offit, K.; Robson, M. E.; Katona, B. W.
Article Title: Summary of the experiences, knowledge, medical management, and family communication of monoallelic MUTYH carriers
Abstract: Germline genetic testing for inherited cancer risk is increasingly being performed with multigene panel testing with MUTYH often included on colorectal cancer- and polyposis-focused panels, as well as on broader pan-cancer panels. With up to 1%–2% of the general population being monoallelic MUTYH carriers, pathogenic/likely pathogenic (P/LP) variants in MUTYH are one of the most common findings on multigene cancer panels. However, little is known about patient experience and understanding of monoallelic MUTYH P/LP variants, nor whether such findings influence medical management recommendations and familial communication, which this study aims to better understand. Monoallelic P/LP MUTYH carriers were recruited from the Prospective Registry of Multiplex Testing (PROMPT) and completed a cross-sectional self-report survey on sociodemographic characteristics, medical and family history, experiences with MUTYH genetic testing, genetics and MUTYH knowledge, perceived cancer risk, and familial communication. Of 115 eligible PROMPT participants, 49 (43%) completed the survey who were primarily female (94%), white (96%), had a history of cancer (61%), and a median age of 51.4 years. Most participants (61%) reported satisfaction with how their healthcare provider managed their genetic test result and care, and 65% of survey participants reported their provider recommended colonoscopy based on their genetic test results. Participants' responses also reflected variable levels of knowledge regarding cancer risks and screening recommendations for MUTYH carriers. The majority (98%) of participants shared their genetic test results with at least some of their relatives; however, only 13% of eligible relatives reportedly underwent cascade testing. Taken together, this study provides needed insight into the overall experiences of monoallelic MUTYH carriers and highlights numerous areas for improvement in clinician education, communication, and management of these individuals. © 2022 National Society of Genetic Counselors.
Keywords: middle aged; genetics; mutation; genetic predisposition to disease; pathology; heterozygote; colorectal neoplasms; colorectal tumor; cross-sectional study; cross-sectional studies; genetic predisposition; genetic screening; genetic testing; risk management; knowledge; polyposis; dna glycosylase muty; mutyh; humans; human; female; cascade testing
Journal Title: Journal of Genetic Counseling
Volume: 32
Issue: 2
ISSN: 1059-7700
Publisher: John Wiley & Sons, Inc.  
Date Published: 2023-04-01
Start Page: 342
End Page: 350
Language: English
DOI: 10.1002/jgc4.1641
PUBMED: 36245263
PROVIDER: scopus
PMCID: PMC10436665
DOI/URL:
Notes: The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF and PubMed -- Source: Scopus
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  1. Kenneth Offit
    791 Offit
  2. Mark E Robson
    681 Robson
  3. Jada Gabrielle Hamilton
    113 Hamilton