Nonoperative management of rectal cancer Review

   


Authors: Williams, H.; Lee, C.; Garcia-Aguilar, J.
Review Title: Nonoperative management of rectal cancer
Abstract: The management of locally advanced rectal cancer has changed drastically in the last few decades due to improved surgical techniques, development of multimodal treatment approaches and the introduction of a watch and wait (WW) strategy. For patients with a complete response to neoadjuvant treatment, WW offers an opportunity to avoid the morbidity associated with total mesorectal excision in favor of organ preservation. Despite growing interest in WW, prospective data on the safety and efficacy of nonoperative management are limited. Challenges remain in optimizing multimodal treatment regimens to maximize tumor regression and in improving the accuracy of patient selection for WW. This review summarizes the history of treatment for rectal cancer and the development of a WW strategy. It also provides an overview of clinical considerations for patients interested in nonoperative management, including restaging strategies, WW selection criteria, surveillance protocols and long-term oncologic outcomes. Copyright © 2024 Williams, Lee and Garcia-Aguilar.
Keywords: surgical technique; review; multimodality cancer therapy; patient selection; side effect; neoadjuvant therapy; radiotherapy; tumor regression; cancer inhibition; drug combination; surgery; organ preservation; drug therapy; rectum cancer; adverse drug reaction; therapy; total mesorectal excision; nonoperative management; locally advanced rectal cancer; human; total neoadjuvant therapy; watch-and-wait; local regrowth
Journal Title: Frontiers in Oncology
Volume: 14
ISSN: 2234-943X
Publisher: Frontiers Media S.A.  
Date Published: 2024-12-06
Start Page: 1477510
Language: English
DOI: 10.3389/fonc.2024.1477510
PROVIDER: scopus
PMCID: PMC11659252
PUBMED: 39711959
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85212457794&doi=10.3389%2ffonc.2024.1477510&partnerID=40&md5=dec386f438f9dd71af69317e703895c6
Notes: Review -- MSK corresponding author is Julio Garcia-Aguilar -- Source: Scopus
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MSK Authors
  1. Julio Garcia Aguilar
    350 Garcia Aguilar
  2. Hannah Williams
    24 Williams
  3. Christina Inbok Lee
    6 Lee
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