PIWI-interacting RNAs: Who, what, when, where, why, and how Editorial
| Authors: | Haase, A. D.; Ketting, R. F.; Lai, E. C.; van Rij, R. P.; Siomi, M.; Svoboda, P.; van Wolfswinkel, J. C.; Wu, P. H. |
| Title: | PIWI-interacting RNAs: Who, what, when, where, why, and how |
| Abstract: | PIWI-interacting RNAs (piRNA) suppress selfish genetic elements and are essential for germ cell biology in animals. They also play critical roles in regeneration in planaria, regulate gene expression in adult mammalian testes, and participate in antiviral defense in mosquitoes. Inspired by a recent workshop on PIWI proteins and piRNAs, this commentary aims to summarize fundamental aspects of piRNA biology, highlight recent advances, and discuss key outstanding questions. It is written by and for biochemists, geneticists, and evolutionary biologists, and represents our interdisciplinary perspective. © This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2024. |
| Keywords: | protein expression; nonhuman; note; pachytene; cytology; gene expression; genetic transcription; epigenetics; gene control; innate immunity; genome; gene silencing; enzyme kinetics; loss of function mutation; argonaute protein; developmental stage; piwi interacting rna; female fertility; antiviral activity; biogenesis; piwi protein; spermatogenesis; histone modification; gametogenesis; human; article |
| Journal Title: | EMBO Journal |
| Volume: | 43 |
| Issue: | 22 |
| ISSN: | 0261-4189 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2024-11-18 |
| Start Page: | 5335 |
| End Page: | 5339 |
| Language: | English |
| DOI: | 10.1038/s44318-024-00253-8 |
| PUBMED: | 39327528 |
| PROVIDER: | scopus |
| PMCID: | PMC11574264 |
| DOI/URL: | |
| Notes: | Note -- Source: Scopus |
