Systemic immunological changes after yttrium-90 radioembolization: A pilot prospective observational study — Clinical insights Journal Article
| Authors: | Kitsel, Y.; Petre, E. N.; Wong, P.; Sotirchos, V.; Vakiani, E.; Dimopoulos, P. M.; Ganesh, K.; Rousseau, B.; Sofocleous, C. T. |
| Article Title: | Systemic immunological changes after yttrium-90 radioembolization: A pilot prospective observational study — Clinical insights |
| Abstract: | Purpose: To prospectively investigate levels of circulating cytokines, changes in frequencies of various immune cell subsets and expression of proliferation and checkpoint molecules on T cells in the peripheral blood after yttrium-90 radioembolization (TARE) of colorectal cancer liver metastases (CLM). Materials and methods: We prospectively collected, isolated, and froze peripheral blood mononuclear cells (PBMC) and plasma samples from 15 patients immediately before, immediately after, 3 and 6 weeks post-TARE of CLM. Plasma samples were assessed for various cytokines using a multiplex immunoassay platform. PBMC samples were analyzed in a monocyte/dendritic cell (DC)/B cell flow panel and a T cell activation/exhaustion flow phenotyping panel. We compared the levels at the respective time points using Wilcoxon signed rank test. Results: IFN-g significantly decreased immediately after (mean 1.62 vs. 3.02 at baseline, p = 0.04) and increased at 6 weeks compared to the immediately post-TARE nadir (mean 9.42 vs. 1.62, p = 0.04). IL-10 decreased at 3 weeks (mean 0.36 vs. 1.75, p = 0.025) post-TARE compared to baseline. Increased CD3+T cells (mean 78.24 vs. 60.8, p = 0.002) and decreased CTLA-4+CD4+T cells (mean 2.58 vs. 4.41, p = 0.033) were observed at 3 weeks compared to baseline. Increased Ki-67+ proliferating CD8+T cells at 3 and 6 weeks (mean 7.28 and 9.06, respectively, vs. 3.93 at baseline, p = 0.02 and 0.03) were recorded. Conclusion: A shift toward a favorable antitumoral cytokinic and immune cells response was observed after TARE. Significant changes were in specialized immune cells subsets playing important roles in the activation of the immune system. These results support trials combining TARE with immunotherapy for patients with CLM. Graphical Abstract: (Figure presented.) © Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2024. |
| Keywords: | adult; clinical article; controlled study; treatment response; aged; middle aged; liver neoplasms; radiation dose; flow cytometry; follow up; prospective study; prospective studies; colorectal cancer; cd8+ t lymphocyte; tumor associated leukocyte; phenotype; interleukin 2; dendritic cell; tumor volume; radiotherapy; interleukin 10; interleukin 4; interleukin 5; interleukin 7; gene frequency; pathology; cancer therapy; enzyme linked immunosorbent assay; colorectal neoplasms; liver metastasis; cytokine; blood; immunology; cytokines; immune response; mononuclear cell; leukocytes, mononuclear; gamma interferon; pilot study; pilot projects; colorectal tumor; liver tumor; cd4+ t lymphocyte; interleukin 6; tumor immunity; cytokine production; immunoassay; interleukin 17; th17 cell; monocyte; observational study; cytotoxic t lymphocyte antigen 4; cell activation; therapy; yttrium; embolization, therapeutic; yttrium radioisotopes; antigen presenting cell; immunocompetent cell; peripheral blood mononuclear cell; tumor necrosis factor; introspection; kidney transplantation; programmed death 1 ligand 1; programmed death 1 receptor; interleukin 23; microsphere; yttrium 90; procedures; radioembolization; immunological parameters; yttrium-90; humans; human; male; female; article; colorectal cancer liver metastases; artificial embolization; yttrium-90 radioembolization; immune oncology |
| Journal Title: | CardioVascular and Interventional Radiology |
| Volume: | 47 |
| Issue: | 11 |
| ISSN: | 0174-1551 |
| Publisher: | Springer |
| Date Published: | 2024-11-01 |
| Start Page: | 1461 |
| End Page: | 1470 |
| Language: | English |
| DOI: | 10.1007/s00270-024-03870-2 |
| PUBMED: | 39406871 |
| PROVIDER: | scopus |
| PMCID: | PMC12083698 |
| DOI/URL: | |
| Notes: | Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PubMed and PDF -- MSK corresponding author is Constantinos Sofocleous -- Source: Scopus |
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