Fertility outcomes post immune checkpoint inhibitor exposure Research Letter


Authors: Harrold, E. C.; Ogle, M.; O'Brien, E.; Wilde, C.; Sinopoli, J.; Weiss, J.; Martino, L.; Casson, A.; Kang, H. J.; Postow, M.; Cercek, A.
Title: Fertility outcomes post immune checkpoint inhibitor exposure
Abstract: Harrold et al. evaluate the fertility impact of checkpoint inhibitor (ICB) exposure, demonstrating that unlike in utero exposure, post-exposure conception appears to result in uncomplicated pregnancies and healthy progeny. They demonstrate contemporaneous monitoring of temporal female hormonal fluctuations before, on, and post ICB exposure and prior to successful embryo implantation. © 2024 Elsevier Inc.
Keywords: letter; neoplasm; neoplasms; drug effect; immunology; progeny; pregnancy; drug therapy; fertility; drug exposure; nidation; immune checkpoint inhibitor; humans; human; female; immune checkpoint inhibitors; prenatal exposure
Journal Title: Cancer Cell
Volume: 42
Issue: 11
ISSN: 1535-6108
Publisher: Cell Press  
Date Published: 2024-11-11
Start Page: 1808
End Page: 1810
Language: English
DOI: 10.1016/j.ccell.2024.10.005
PUBMED: 39486412
PROVIDER: scopus
DOI/URL:
Notes: Letter -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PDF -- MSK corresponding author is Andrea Cercek -- Source: Scopus
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MSK Authors
  1. Michael Andrew Postow
    361 Postow
  2. Anne Regan Casson
    23 Casson
  3. Jenna Lynn Cohen
    12 Cohen
  4. Jill A Weiss
    10 Weiss
  5. Martinique M. Ogle
    3 Ogle
  6. Emily Catherine Harrold
    18 Harrold
  7. Callahan Wilde
    3 Wilde