“Fit for purpose” (64)Cu labeled liposome formulations specialized for enriched targeting to 1) bone marrow spleen; 2) lymph nodes; or 3) tumor Book Section
| Authors: | Lee, S. G.; Pillarsetty, K.; Larson, S. M. |
| Editor: | Jekunen, Antti |
| Article/Chapter Title: | “Fit for purpose” (64)Cu labeled liposome formulations specialized for enriched targeting to 1) bone marrow spleen; 2) lymph nodes; or 3) tumor |
| Abstract: | Upon intravenous injection, liposomal particles are rapidly cleared from the blood by fixed macrophages in the liver, spleen, bone marrow and lymph nodes i.e. specialized cells of the innate immune system. By reducing the affinity for these fixed macrophages, therapeutic liposomes containing drugs have been used to target tumor by the Enhanced Permeability and Retention (EPR) effect. In this communication, we report minor modifications of lipid compositions that result in the production of 3 classes of liposomes, each suitable for enhanced selectivity of uptake in 1) Bone Marrow/Spleen (SBMT Lipo); 2) Lymph Nodes (LNT Lipo); and 3) Tumor (TT Lipo). © 2022, Bentham Books imprint. All rights reserved. |
| Keywords: | nanoparticles; pet; tumor imaging; reticuloendothelial system; lymph node imaging; copper-64; bone marrow imaging; endothelial macrophages |
| Book Title: | The Evolution of Radionanotargeting towards Clinical Precision Oncology: A Festschrift in Honor of Kalevi Kairemo |
| ISBN: | 978-1-68108-866-2 |
| Publisher: | Bentham Science Publishers |
| Publication Place: | Sharjah, UAE |
| Date Published: | 2022-01-01 |
| Start Page: | 272 |
| End Page: | 276 |
| Language: | English |
| DOI: | 10.2174/9781681088655122010025 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Book chapter: 22 -- Source: Scopus |
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