A comparative review of Aphexda and Mozobil for mobilization prior to stem cell collection Review
| Authors: | Dietz, L.; Marini, J.; Hashmi, H.; McGann, M. |
| Review Title: | A comparative review of Aphexda and Mozobil for mobilization prior to stem cell collection |
| Abstract: | High-dose chemotherapy followed by autologous hematopoietic stem cell transplantation is the standard of care for eligible patients with newly diagnosed multiple myeloma leading to prolonged progression free and overall survival. Successful engraftment following hematopoietic stem cell infusion requires adequate stem cell doses. Current mobilization regimens include granulocyte colony-stimulating factor (G-CSF) with or without plerixafor. Motixafortide is a recently approved agent that can be used in combination with G-CSF for mobilization. In the absence of any head-to-head trials comparing the two products, this article aims to outline the similarities and differences of these two agents. Though moxitafortide has a more favorable pharmacokinetic profile in comparison to plerixafor, in clinical trials, the agents demonstrated similar efficacy. In addition, the use of motixafortide in clinical practice may be limited by product cost as well as administration and monitoring requirements. © The Author(s) 2024. |
| Keywords: | cancer chemotherapy; drug tolerability; review; drug efficacy; drug safety; drug approval; comparative study; antineoplastic agent; clinical practice; multiple myeloma; hematopoietic stem cell transplantation; food and drug administration; stem cell; drug hypersensitivity; drug cost; stem cell mobilization; drug monitoring; drug therapy; granulocyte colony stimulating factor; granulocyte colony-stimulating factor; plerixafor; hematopoietic stem cell mobilization; heterocyclic compounds; transplantation, autologous; therapy; heterocyclic compound; autologous hematopoietic stem cell transplantation; pharmacokinetic parameters; autotransplantation; mobilization; procedures; autologous transplant; combination drug therapy; pharmacological parameters; humans; human; cyclam derivative; motixafortide; benzylamines; benzylamine derivative; cyclams |
| Journal Title: | Journal of Oncology Pharmacy Practice |
| Volume: | 30 |
| Issue: | 6 |
| ISSN: | 1078-1552 |
| Publisher: | Sage Publications Ltd. |
| Date Published: | 2024-09-01 |
| Start Page: | 1073 |
| End Page: | 1077 |
| Language: | English |
| DOI: | 10.1177/10781552241247472 |
| PUBMED: | 38629183 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Source: Scopus |
