Upfront use of plerixafor and granulocyte-colony stimulating factor (GCSF) for stem cell mobilization in patients with multiple myeloma: Efficacy and analysis of risk factors associated with poor stem cell collection efficiency* Journal Article


Authors: Ogunniyi, A.; Rodriguez, M.; Devlin, S.; Adel, N.; Landau, H.; Chung, D. J.; Lendvai, N.; Lesokhin, A.; Koehne, G.; Mailankody, S.; Korde, N.; Reich, L.; Landgren, O.; Giralt, S.; Hassoun, H.
Article Title: Upfront use of plerixafor and granulocyte-colony stimulating factor (GCSF) for stem cell mobilization in patients with multiple myeloma: Efficacy and analysis of risk factors associated with poor stem cell collection efficiency*
Abstract: Plerixafor (P), an agent that selectively and reversibly binds to the chemokine receptor CXCR4, has been approved in combination with G-CSF (P + G-CSF) for stem cell (SC) mobilization in patients with multiple myeloma (MM). The goal of this study was to determine the SC collection success rate of P + G-CSF using a clinically relevant outcome defined as the ability to collect at least 5 × 106 CD34+ cells/kg to allow safely two transplants, and identify risk factors impacting SC mobilization. One hundred and thirty-eight patients were mobilized with P + G-CSF upfront following induction. The SC collection success rate was 92.8%. We identified exposure to lenalidomide alone (p =.038), WBC count <4 × 103/mcL prior to mobilization (p =.01) and non-African American race (p =.019), as risk factors for low efficiency by multivariate analysis. This study demonstrates that P + G-CSF is highly efficient in MM patients and provides strong support for its upfront use in SC collection for MM patients. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Keywords: multiple myeloma; risk factors; stem cell; plerixafor; efficiency; mobilization
Journal Title: Leukemia and Lymphoma
Volume: 58
Issue: 5
ISSN: 1042-8194
Publisher: Taylor & Francis Group  
Date Published: 2017-01-01
Start Page: 1123
End Page: 1129
Language: English
DOI: 10.1080/10428194.2016.1239261
PROVIDER: scopus
PUBMED: 27735212
PMCID: PMC5640442
DOI/URL:
Notes: Article -- Export Date: 2 March 2017 -- Source: Scopus
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MSK Authors
  1. Sergio Andres Giralt
    516 Giralt
  2. Hani Hassoun
    146 Hassoun
  3. Guenther Koehne
    174 Koehne
  4. Heather Jolie Landau
    180 Landau
  5. Nikoletta Lendvai
    83 Lendvai
  6. Lilian M Reich
    65 Reich
  7. Alexander Meyer Lesokhin
    115 Lesokhin
  8. David Chung
    78 Chung
  9. Carl Ola Landgren
    188 Landgren
  10. Neha Sanat Korde
    62 Korde