Immunotherapy and transarterial embolization in patients with metastatic melanoma: A retrospective cohort study Journal Article

   


Authors: Haghani, L.; Zhan, C.; Yarmohammadi, H.; Ziv, E.; Sotirchos, V. S.; Sarkar, D.; Shoushtari, A. N.; Erinjeri, J. P.
Article Title: Immunotherapy and transarterial embolization in patients with metastatic melanoma: A retrospective cohort study
Abstract: Aim: To investigate how the sequence of checkpoint immunotherapy (CPI) and transarterial embolization (TAE) affects overall survival (OS) of patients with metastatic melanoma. Materials & methods: This retrospective cohort study included 65 patients with metastatic melanoma who underwent both TAE and CPI between September 2011 and January 2022. Results: Significantly higher OS was seen in patients who received CPI before and after embolization (22 months, 95% CI 14-NR, p < 0.001) compared with only before embolization (4.5 months 95% CI, 14-NR). ≤3 hepatic metastasis (p < 0.01), more TAE procedures (p < 0.001) and CPI sequence (before and after embolization) (p < 0.001) were independent predictors of survival. Conclusion: Metastatic melanoma patients who underwent TAE have longer survival when CPI was sequenced both before and after embolization. © 2024 Informa UK Limited, trading as Taylor & Francis Group.
Keywords: adult; aged; middle aged; retrospective studies; major clinical study; overall survival; mortality; liver neoplasms; comparative study; cancer immunotherapy; melanoma; metastasis; cohort studies; skin neoplasms; cohort analysis; pathology; retrospective study; liver metastasis; skin tumor; immunotherapy; liver tumor; neoplasm metastasis; interventional radiology; predictor variable; therapy; embolization, therapeutic; metastatic melanoma; procedures; arterial embolization; immune checkpoint inhibitor; cancer prognosis; long term survival; humans; human; male; female; article; timing; checkpoint inhibitor; transarterial embolization; immune checkpoint inhibitors; artificial embolization; treatment sequence
Journal Title: Immunotherapy
Volume: 16
Issue: 14-15
ISSN: 1750-743X
Publisher: Future Medicine  
Date Published: 2024-01-01
Start Page: 955
End Page: 962
Language: English
DOI: 10.1080/1750743x.2024.2382665
PUBMED: 39225651
PROVIDER: scopus
PMCID: PMC11485943
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85203090342&doi=10.1080%2f1750743X.2024.2382665&partnerID=40&md5=7c1fc1bcd706a4dd3584bd2161c63c4f
Notes: Source: Scopus
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MSK Authors
  1. Joseph Patrick Erinjeri
    204 Erinjeri
  2. Alexander Noor Shoushtari
    247 Shoushtari
  3. Hooman Yarmohammadi
    133 Yarmohammadi
  4. Etay Ziv
    116 Ziv
  5. Vlasios S Sotirchos
    61 Sotirchos
  6. Chenyang Zhan
    9 Zhan
  7. Debkumar Sarkar
    14 Sarkar
  8. Leila Haghani
    7 Haghani
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