Updates in chronic graft-versus-host disease: Novel treatments and best practices in the current era Review
| Authors: | Vadakkel, G.; Eng, S.; Proli, A.; Ponce, D. M. |
| Review Title: | Updates in chronic graft-versus-host disease: Novel treatments and best practices in the current era |
| Abstract: | Chronic graft-versus-host disease (cGVHD) is a serious complication of allogeneic hematopoietic cell transplant. The development of cGVHD involves a complex, multistep process that is characterized by early inflammation and tissue injury, followed by chronic inflammation, aberrant tissue repair, and fibrosis. Systemic corticosteroids remain the first line of treatment for cGVHD. New treatments for patients with cGVHD for whom treatment has failed or who develop steroid-dependent cGVHD are now available; these include ibrutinib, ruxolitinib, and belumosudil. Treatment selection may be based on the patient’s individual needs, graft-versus-host disease organ involvement, and comorbidities. However, as therapeutic options for patients without a treatment response or with only a partial response remain an unmet need, new agents are under investigation. Furthermore, patients with cGVHD can develop multiorgan involvement and frequently require specialized care. A multidisciplinary team approach that focuses on the individual’s needs and quality of life is strongly encouraged. © The Author(s), under exclusive licence to Springer Nature Limited 2024. |
| Keywords: | adult; treatment response; review; side effect; quality of life; inflammation; steroid; hematopoietic stem cell transplantation; chronic disease; chronic graft versus host disease; comorbidity; graft versus host reaction; graft rejection; corticosteroid; drug therapy; graft vs host disease; therapy; tissue repair; chronic inflammation; prevention; etiology; adverse event; choristoma; ruxolitinib; ibrutinib; humans; human; female; best practice; pharmacoeconomics; multidisciplinary team; line of treatment; unexpected outcome of drug treatment; belumosudil |
| Journal Title: | Bone Marrow Transplantation |
| Volume: | 59 |
| Issue: | 10 |
| ISSN: | 0268-3369 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2024-10-01 |
| Start Page: | 1360 |
| End Page: | 1368 |
| Language: | English |
| DOI: | 10.1038/s41409-024-02370-8 |
| PUBMED: | 39080470 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledge in the PDF -- Corresponding authors are MSK authors: Grashma Vadakke and Doris M. Ponce -- Source: Scopus |
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