Increasing incidence of chronic graft-versus-host disease in allogeneic transplantation: A report from the Center for International Blood and Marrow Transplant Research Journal Article

   

Authors:	Arai, S.; Arora, M.; Wang, T.; Spellman, S. R.; He, W.; Couriel, D. R.; Urbano-Ispizua, A.; Cutler, C. S.; Bacigalupo, A. A.; Battiwalla, M.; Flowers, M. E.; Juckett, M. B.; Lee, S. J.; Loren, A. W.; Klumpp, T. R.; Prockop, S. E.; Ringdén, O. T. H.; Savani, B. N.; Socié, G.; Schultz, K. R.; Spitzer, T.; Teshima, T.; Bredeson, C. N.; Jacobsohn, D. A.; Hayashi, R. J.; Drobyski, W. R.; Frangoul, H. A.; Akpek, G.; Ho, V. T.; Lewis, V. A.; Gale, R. P.; Koreth, J.; Chao, N. J.; Aljurf, M. D.; Cooper, B. W.; Laughlin, M. J.; Hsu, J. W.; Hematti, P.; Verdonck, L. F.; Solh, M. M.; Norkin, M.; Reddy, V.; Martino, R.; Gadalla, S.; Goldberg, J. D.; McCarthy, P. L.; Pérez-Simón, J. A.; Khera, N.; Lewis, I. D.; Atsuta, Y.; Olsson, R. F.; Saber, W.; Waller, E. K.; Blaise, D.; Pidala, J. A.; Martin, P. J.; Satwani, P.; Bornhäuser, M.; Inamoto, Y.; Weisdorf, D. J.; Horowitz, M. M.; Pavletic, S. Z.
Article Title:	Increasing incidence of chronic graft-versus-host disease in allogeneic transplantation: A report from the Center for International Blood and Marrow Transplant Research
Abstract:	Although transplant practices have changed over the last decades, no information is available on trends in incidence and outcome of chronic graft-versus-host disease (cGVHD) over time. This study used the central database of the Center for International Blood and Marrow Transplant Research (CIBMTR) to describe time trends for cGVHD incidence, nonrelapse mortality, and risk factors for cGVHD. The 12-year period was divided into 3 intervals, 1995 to 1999, 2000 to 2003, and 2004 to 2007, and included 26,563 patients with acute leukemia, chronic myeloid leukemia, and myelodysplastic syndrome. Multivariate analysis showed an increased incidence of cGVHD in more recent years (odds ratio=1.19, P<.0001), and this trend was still seen when adjusting for donor type, graft type, or conditioning intensity. In patients with cGVHD, nonrelapse mortality has decreased over time, but at 5years there were no significant differences among different time periods. Risk factors for cGVHD were in line with previous studies. This is the first comprehensive characterization of the trends in cGVHD incidence and underscores the mounting need for addressing this major late complication of transplantation in future research.
Keywords:	adolescent; adult; child; middle aged; young adult; major clinical study; overall survival; mortality; outcome assessment; incidence; chronic myeloid leukemia; risk factor; acute leukemia; chronic graft versus host disease; myelodysplastic syndrome; infant; newborn; allogeneic hematopoietic stem cell transplantation; allogeneic transplant; human; male; female; article; cgvhd; nonrelapse mortality
Journal Title:	Biology of Blood and Marrow Transplantation
Volume:	21
Issue:	2
ISSN:	1083-8791
Publisher:	Elsevier Inc.
Date Published:	2015-02-01
Start Page:	266
End Page:	274
Language:	English
DOI:	10.1016/j.bbmt.2014.10.021
PROVIDER:	scopus
PUBMED:	25445023
PMCID:	PMC4326247
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-84920903701&partnerID=40&md5=0065007e31ede85a7f98944f71cee253
Notes:	Export Date: 2 February 2015 -- Source: Scopus

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