Infectious disease considerations in chronic graft-versus-host disease and transplantation survivors Review
| Authors: | Epstein, D. J.; Otoukesh, S.; Shahid, Z.; Dadwal, S. S. |
| Review Title: | Infectious disease considerations in chronic graft-versus-host disease and transplantation survivors |
| Abstract: | Chronic graft-versus-host disease is a frequent and serious complication of allogeneic hematopoietic cell transplantation and is associated with an increased risk of serious infections. Impaired humoral immunity increases the risk of recurrent or severe sinopulmonary infections, and functional asplenia predisposes to infections from encapsulated organisms. Herpesvirus infections and community-acquired respiratory viral infections are problematic as well. Pneumocystis pneumonia remains a risk, and mold infections occur in some patients. Understanding the epidemiology and pathophysiology of these infections is important for determining optimal monitoring and prophylaxis, and guiding patient counseling. © 2024 The American Society for Transplantation and Cellular Therapy |
| Keywords: | adult; aged; major clinical study; review; pathophysiology; pneumocystis pneumonia; hematopoietic stem cell transplantation; survivor; survivors; chronic disease; chronic graft versus host disease; graft versus host reaction; epidemiology; drug therapy; graft vs host disease; humoral immunity; patient counseling; communicable disease; prevention; adverse event; communicable diseases; herpes virus infection; infections; chronic gvhd; humans; human; male; unexpected outcome of drug treatment; functional asplenia; sinopulmonary infection |
| Journal Title: | Transplantation and Cellular Therapy |
| Volume: | 30 |
| Issue: | 9 |
| ISSN: | 2666-6375 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2024-09-01 |
| Start Page: | S534 |
| End Page: | S547 |
| Language: | English |
| DOI: | 10.1016/j.jtct.2024.05.019 |
| PUBMED: | 39370235 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
