Aberrant pre-mRNA processing in cancer Review
| Authors: | Biswas, J.; Boussi, L.; Stein, E.; Abdel-Wahab, O. |
| Review Title: | Aberrant pre-mRNA processing in cancer |
| Abstract: | This review describes the current state of understanding of how RNA processing is dysregulated in cancer (including alterations in RNA splicing, capping, polyadenylation, and decay) and how this knowledge is being harnessed for therapeutic intent. Dysregulation of the flow of information from genomic DNA to RNA to protein occurs within all cancer types. In this review, we described the current state of understanding of how RNA processing is dysregulated in cancer with a focus on mutations in the RNA splicing factor machinery that are highly prevalent in hematologic malignancies. We discuss the downstream effects of these mutations highlighting both individual genes as well as common pathways that they perturb. We highlight examples of how alterations in RNA processing have been harnessed for therapeutic intent as well as to promote the selective toxicity of cancer cells. |
| Keywords: | leukemia; inhibitor; myelodysplastic syndromes; modulation; gene-expression; uveal melanoma; driver mutations; splicing factor sf3b1; intron retention; 1st-in-human phase-i |
| Journal Title: | Journal of Experimental Medicine |
| Volume: | 221 |
| Issue: | 11 |
| ISSN: | 0022-1007 |
| Publisher: | Rockefeller University Press |
| Date Published: | 2024-11-04 |
| Start Page: | e20230891 |
| Language: | English |
| ACCESSION: | WOS:001319243900001 |
| DOI: | 10.1084/jem.20230891 |
| PROVIDER: | Clarivate Analytics Web of Science |
| PROVIDER: | wos |
| PMCID: | PMC11448470 |
| PUBMED: | 39316554 |
| Notes: | Review -- e20230891 -- Source: Wos |
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