Dysregulation and therapeutic targeting of RNA splicing in cancer Review

  


Authors: Stanley, R. F.; Abdel-Wahab, O.
Review Title: Dysregulation and therapeutic targeting of RNA splicing in cancer
Abstract: High-throughput sequencing and functional characterization of the cancer transcriptome have uncovered cancer-specific dysregulation of RNA splicing across a variety of cancers. Alterations in the cancer genome and dysregulation of RNA splicing factors lead to missplicing, splicing alteration-dependent gene expression and, in some cases, generation of novel splicing-derived proteins. Here, we review recent advances in our understanding of aberrant splicing in cancer pathogenesis and present strategies to harness cancer-specific aberrant splicing for therapeutic intent. © 2022, Springer Nature America, Inc.
Keywords: chronic myelomonocytic leukemia; gene mutation; genetics; missense mutation; review; cancer growth; nonhuman; neoplasm; neoplasms; cell cycle; protein bcl 2; melanoma; apoptosis; breast cancer; gene expression; serine; protein protein interaction; cell differentiation; protein bcl xl; bladder cancer; rna binding protein; tumor suppressor gene; myelodysplastic syndrome; nonhodgkin lymphoma; lung adenocarcinoma; immune response; protein processing; messenger rna; systematic review; mismatch repair; protein mcl 1; medulloblastoma; pancreas adenocarcinoma; threonine; spliceosome; uvea melanoma; major histocompatibility complex; chronic lymphatic leukemia; glutamic acid; oligonucleotide; small nuclear ribonucleoprotein; rna polymerase ii; dinucleotide; genomic dna; rna splicing; dna methyltransferase 3b; rna sequence; proline; messenger rna precursor; duchenne muscular dystrophy; muscle atrophy; protein rna binding; protein arginine methyltransferase; open reading frame; polyadenylation; acute myeloid leukemia; small nuclear rna; protein bcl x; genomic rna; humans; human; rna splicing factor; rna splicing factors; malignant neoplasm; elongation factor 3
Journal Title: Nature Cancer
Volume: 3
Issue: 5
ISSN: 2662-1347
Publisher: Nature Research  
Date Published: 2022-05-01
Start Page: 536
End Page: 546
Language: English
DOI: 10.1038/s43018-022-00384-z
PUBMED: 35624337
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85130855221&doi=10.1038%2fs43018-022-00384-z&partnerID=40&md5=5db0c11ecbec2f8c88ab1fd87dd23b1a
Notes: Review -- Export Date: 1 July 2022 -- Source: Scopus
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MSK Authors
  1. Omar Ibrahim Abdel-Wahab
    573 Abdel-Wahab
  2. Robert Stanley
    12 Stanley
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