A guideline on the molecular ecosystem regulating ferroptosis Review
| Authors: | Dai, E.; Chen, X.; Linkermann, A.; Jiang, X.; Kang, R.; Kagan, V. E.; Bayir, H.; Yang, W. S.; Garcia-Saez, A. J.; Ioannou, M. S.; Janowitz, T.; Ran, Q.; Gu, W.; Gan, B.; Krysko, D. V.; Zhu, X.; Wang, J.; Krautwald, S.; Toyokuni, S.; Xie, Y.; Greten, F. R.; Yi, Q.; Schick, J.; Liu, J.; Gabrilovich, D. I.; Liu, J.; Zeh, H. J.; Zhang, D. D.; Yang, M.; Iovanna, J.; Kopf, M.; Adolph, T. E.; Chi, J. T.; Li, C.; Ichijo, H.; Karin, M.; Sankaran, V. G.; Zou, W.; Galluzzi, L.; Bush, A. I.; Li, B.; Melino, G.; Baehrecke, E. H.; Lotze, M. T.; Klionsky, D. J.; Stockwell, B. R.; Kroemer, G.; Tang, D. |
| Review Title: | A guideline on the molecular ecosystem regulating ferroptosis |
| Abstract: | Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid peroxidation, has garnered substantial interest since this term was first coined in 2012. Recent years have witnessed remarkable progress in elucidating the detailed molecular mechanisms that govern ferroptosis induction and defence, with particular emphasis on the roles of heterogeneity and plasticity. In this Review, we discuss the molecular ecosystem of ferroptosis, with implications that may inform and enable safe and effective therapeutic strategies across a broad spectrum of diseases. © Springer Nature Limited 2024. |
| Keywords: | signal transduction; genetics; review; nonhuman; animal; metabolism; animals; cell death; iron; reactive oxygen species; reactive oxygen metabolite; lipid peroxidation; therapy; ferroptosis; humans; human |
| Journal Title: | Nature Cell Biology |
| Volume: | 26 |
| Issue: | 9 |
| ISSN: | 1465-7392 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2024-09-01 |
| Start Page: | 1447 |
| End Page: | 1457 |
| Language: | English |
| DOI: | 10.1038/s41556-024-01360-8 |
| PUBMED: | 38424270 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PubMed -- Source: Scopus |
