Multiplexed serial imaging of immunotherapy response with SERRS nanoprobes Conference Paper

  


Authors: Berisha, N.; Plakas, K.; Gigoux, M.; Merghoub, T.; Andreou, C.
Title: Multiplexed serial imaging of immunotherapy response with SERRS nanoprobes
Conference Title: 2024 IEEE 21st International Symposium on Biomedical Imaging (ISBI)
Abstract: With the advent of new and promising cancer therapies, and with increased interest in precision medicine, there is an urgent need to develop non-invasive technologies that evaluate heterogeneity in treatment response. We demonstrate an 8-plex imaging platform based on surface enhanced resonance Raman scattering nanoparticles (SERRS NPs) to monitor the expression of 4 immunomarkers before and after treatment with checkpoint blockade therapy with anti-CTLA4 and anti-PD-1 antibodies in immunotherapy models of colon (CT26) and breast (4T1) cancers. We found that CT26 tumors showed an early treatment response, while the typically refractory 4T1 tumors demonstrated an unexpected treatment response, suggesting that the nanoparticles may have synergistically contributed to the treatment. Serial imaging of multiple markers during therapy can help predict treatment efficacy and uncover new theranostic adjuvants. © 2024 IEEE.
Keywords: treatment response; molecular imaging; cancer therapy; immunotherapy; computerized tomography; nanoparticles; raman spectroscopy; raman scattering; surface-enhanced resonance raman scattering; enhanced raman scattering; surface enhanced raman; surface enhanced raman scattering; multiplexed molecular imaging; nanoclay; non-invasive technology; serial imaging
Journal Title International Symposium on Biomedical Imaging. Proceedings
Conference Dates: 2024 May 27-30
Conference Location: Athens, Greece
ISBN: 1945-7928
Publisher: IEEE  
Date Published: 2024-01-01
Language: English
DOI: 10.1109/isbi56570.2024.10635334
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85203370670&doi=10.1109%2fISBI56570.2024.10635334&partnerID=40&md5=111e670a44a3df9c8112924438e6685d
Notes: The MSK Cancer Center Support Grant (P30 CA008748) is acknowledge in the PDF -- Source: Scopus
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MSK Authors
  1. Taha Merghoub
    364 Merghoub
  2. Chrysafis Andreou
    22 Andreou
  3. Mathieu Gigoux
    23 Gigoux
  4. Naxhije Berisha
    11 Berisha
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