Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy Journal Article

   


Authors: Min, Y.; Roche, K. C.; Tian, S.; Eblan, M. J.; McKinnon, K. P.; Caster, J. M.; Chai, S.; Herring, L. E.; Zhang, L.; Zhang, T.; DeSimone, J. M.; Tepper, J. E.; Vincent, B. G.; Serody, J. S.; Wang, A. Z.
Article Title: Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy
Abstract: Immunotherapy holds tremendous promise for improving cancer treatment(1). To administer radiotherapy with immunotherapy has been shown to improve immune responses and can elicit the 'abscopal effect'(2). Unfortunately, response rates for this strategy remain low(3). Herein we report an improved cancer immunotherapy approach that utilizes antigen-capturing nanoparticles (AC-NPs). We engineered several AC-NP formulations and demonstrated that the set of protein antigens captured by each AC-NP formulation is dependent on the NP surface properties. We showed that AC-NPs deliver tumour-specific proteins to antigen-presenting cells (APCs) and significantly improve the efficacy of alpha PD-1 (anti-programmed cell death 1) treatment using the B16F10 melanoma model, generating up to a 20% cure rate compared with 0% without AC-NPs. Mechanistic studies revealed that AC-NPs induced an expansion of CD8+ cytotoxic T cells and increased both CD4(+)T/T-reg and CD8(+)T/T-reg ratios (T-reg, regulatory T cells). Our work presents a novel strategy to improve cancer immunotherapy with nanotechnology.
Keywords: melanoma; radiation; radiotherapy; safety; antibody; nanotechnology; responses; mechanisms; blockade; neoantigens
Journal Title: Nature Nanotechnology
Volume: 12
Issue: 9
ISSN: 1748-3387
Publisher: Nature Publishing Group  
Date Published: 2017-09-01
Start Page: 877
End Page: 882
Language: English
ACCESSION: WOS:000409361800013
DOI: 10.1038/nnano.2017.113
PROVIDER: wos
PMCID: PMC5587366
PUBMED: 28650437
Notes: Correction issued, see DOI: 10.1038/s41565-021-00864-w -- Article -- Source: Wos
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