Myeloid neoplasms postcytotoxic therapy in children Journal Article
| Author: | Shukla, N. |
| Article Title: | Myeloid neoplasms postcytotoxic therapy in children |
| Abstract: | Myeloid neoplasms postcytotoxic therapy (MN-pCT) in children represent a heterogeneous group of neoplasms which primarily arise following exposure to alkylating agents, topoisomerase inhibitors, and radiotherapy. Outcomes remain poor despite aggressive chemotherapeutic approaches and allogeneic hematopoietic stem cell transplantation (HSCT). Although there are shared features between childhood and adult-onset disease, recent studies of pediatric onset MN-pCT suggest unique pathophysiology with distinctive genomic features and lack of pre-existing clonal hematopoiesis clones susceptible to transformation. Future studies prospectively evaluating the utility of tracking molecular evidence of development of MN-pCT in children exposed to cytotoxic agents could lead to early detection and potentially more effective interventions for patients. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2024. |
| Keywords: | cancer chemotherapy; child; overall survival; cytarabine; dna replication; dna damage; apoptosis; anemia; radiotherapy; prevalence; cytogenetics; alkylating agent; risk factor; chlormethine; acute lymphoblastic leukemia; bone marrow biopsy; daunorubicin; graft versus host reaction; asparaginase; allogeneic hematopoietic stem cell transplantation; immunophenotyping; multivariate analysis; dna topoisomerase inhibitor; drug therapy; alkylating agents; anthracycline; dna topoisomerase (atp hydrolysing); liposome; gyrase inhibitor; aml; mds; standardized incidence ratio; bone marrow tumor; acute myeloid leukemia; razoxane; epipodophyllotoxin; clonal hematopoiesis; high throughput sequencing; topoisomerase inhibitors; human; de novo acute myeloid leukemia; therapy-related myeloid neoplasm; revumenib; myeloid neoplasms postcytotoxic therapy |
| Journal Title: | Pediatric Oncology |
| ISSN: | 1613-5318 |
| Publisher: | Springer |
| Date Published: | 2024-01-01 |
| Start Page: | 211 |
| End Page: | 219 |
| Language: | English |
| DOI: | 10.1007/978-3-031-63366-9_12 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Book Chapter: 12 in "Acute myeloid leukemia in children: Standard of care and future perspectives" ISBN: [978-3-031-63365-2] -- Source: Scopus |
