Basket trials: Past, present, and future Review
| Authors: | Murciano-Goroff, Y. R.; Uppal, M.; Chen, M.; Harada, G.; Schram, A. M. |
| Review Title: | Basket trials: Past, present, and future |
| Abstract: | Large-scale tumor molecular profiling has revealed that diverse cancer histologies are driven by common pathways with unifying biomarkers that can be exploited therapeutically. Disease-agnostic basket trials have been increasingly utilized to test biomarker-driven therapies across cancer types. These trials have led to drug approvals and improved the lives of patients while simultaneously advancing our understanding of cancer biology. This review focuses on the practicalities of implementing basket trials, with an emphasis on molecularly targeted trials.We examine the biologic subtleties of genomic biomarker and patient selection, discuss previous successes in drug development facilitated by basket trials, describe certain novel targets and drugs, and emphasize practical considerations for participant recruitment and study design. This review also highlights strategies for aiding patient access to basket trials. As basket trials become more common, steps to ensure equitable implementation of these studies will be critical for molecularly targeted drug development. |
| Keywords: | biomarkers; tumors; targeted therapy; dose-escalation; open-label; socioeconomic-status; genomic; cancer clinical-trials; advanced solid; molecular oncology; precision oncology; single-arm; basket trials; braf mutants; dabrafenib plus trametinib; biomarker-selected trials; disease-agnostic drug development |
| Journal Title: | Annual Review of Cancer Biology |
| Volume: | 8 |
| ISSN: | 2472-3428 |
| Publisher: | Annual Reviews |
| Date Published: | 2024-01-01 |
| Start Page: | 59 |
| End Page: | 80 |
| Language: | English |
| ACCESSION: | WOS:001278203900004 |
| DOI: | 10.1146/annurev-cancerbio-061421-012927 |
| PROVIDER: | wos |
| PMCID: | PMC11210107 |
| PUBMED: | 38938274 |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledge in the PDF -- Corresponding authors is MSK author: Alison M. Schram -- Source: Wos |
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