Basket studies: Redefining clinical trials in the era of genome-driven oncology Journal Article

   


Authors: Tao, J. J.; Schram, A. M.; Hyman, D. M.
Article Title: Basket studies: Redefining clinical trials in the era of genome-driven oncology
Abstract: Understanding a tumor's detailed molecular profile has become increasingly necessary to deliver the standard of care for patients with advanced cancer. Innovations in both tumor genomic sequencing technology and the development of drugs that target molecular alterations have fueled recent gains in genome-driven oncology care. "Basket studies," or histology-agnostic clinical trials in genomically selected patients, represent one important research tool to continue making progress in this field. We review key aspects of genome-driven oncology care, including the purpose and utility of basket studies, biostatistical considerations in trial design, genomic knowledgebase development, and patient matching and enrollment models, which are critical for translating our genomic knowledge into clinically meaningful outcomes. Copyright ©2018 by Annual Reviews. All rights reserved.
Keywords: knowledgebase; precision medicine; basket trial; genome-driven oncology; basket study
Journal Title: Annual Review of Medicine
Volume: 69
ISSN: 0066-4219
Publisher: Annual Reviews  
Date Published: 2018-01-01
Start Page: 319
End Page: 331
Language: English
DOI: 10.1146/annurev-med-062016-050343
PROVIDER: scopus
PUBMED: 29120700
PMCID: PMC7455011
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041716945&doi=10.1146%2fannurev-med-062016-050343&partnerID=40&md5=1c849a5c49698f5891f5b2bad30c2599
Notes: Article -- Export Date: 1 March 2018 -- Source: Scopus
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MSK Authors
  1. David Hyman
    354 Hyman
  2. Alison Michele Schram
    123 Schram
  3. Jessica Jing Tao
    11 Tao
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