Update in the management of gastroenteropancreatic neuroendocrine tumors Review
| Authors: | Sedlack, A. J. H.; Varghese, D. G.; Naimian, A.; Yazdian Anari, P.; Bodei, L.; Hallet, J.; Riechelmann, R. P.; Halfdanarson, T.; Capdevilla, J.; Del Rivero, J. |
| Review Title: | Update in the management of gastroenteropancreatic neuroendocrine tumors |
| Abstract: | Neuroendocrine neoplasms are a diverse group of neoplasms that can occur in various areas throughout the body. Well-differentiated neuroendocrine tumors (NETs) most often arise in the gastrointestinal tract, termed gastroenteropancreatic neuroendocrine tumors (GEP-NETs). Although GEP-NETs are still uncommon, their incidence and prevalence have been steadily increasing over the past decades. The primary treatment for GEP-NETs is surgery, which offers the best chance for a cure. However, because GEP-NETs are often slow-growing and do not cause symptoms until they have spread widely, curative surgery is not always an option. Significant advances have been made in systemic and locoregional treatment options in recent years, including peptide-receptor radionuclide therapy with α and β emitters, somatostatin analogs, chemotherapy, and targeted molecular therapies. © 2024 American Cancer Society. |
| Keywords: | adult; clinical article; review; pancreatic neoplasms; radiotherapy; prevalence; pathology; neuroendocrine tumor; gastrointestinal neoplasms; pancreas tumor; delayed diagnosis; drug therapy; intestine tumor; intestinal neoplasms; stomach neoplasms; therapy; stomach tumor; somatostatin; neuroendocrine tumors; neuroendocrine carcinoma; molecularly targeted therapy; gastrointestinal tumor; molecular targeted therapy; gastroenteropancreatic neuroendocrine tumor; procedures; humans; human; peptide receptor radionuclide therapy; gastro-enteropancreatic neuroendocrine tumor |
| Journal Title: | Cancer |
| Volume: | 130 |
| Issue: | 18 |
| ISSN: | 0008-543X |
| Publisher: | Wiley Blackwell |
| Date Published: | 2024-09-15 |
| Start Page: | 3090 |
| End Page: | 3105 |
| Language: | English |
| DOI: | 10.1002/cncr.35463 |
| PUBMED: | 39012928 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Source: Scopus |
