COX inhibition with anti-PD-1 in advanced dMMR colorectal cancer: Improving antigen presentation? Editorial

  


Authors: Rousseau, B.; Johannet, P.
Title: COX inhibition with anti-PD-1 in advanced dMMR colorectal cancer: Improving antigen presentation?
Abstract: dMMR tumors, which have high tumor mutational and neoantigen burdens, are highly responsive to immune checkpoint blockade. Wu et al.1 showed that combining COX inhibitors with PD-1 blockade could be a safe and effective treatment option for dMMR metastatic colorectal cancer. The study highlights the potential of this combination therapy in achieving deep and long-lasting responses in dMMR colorectal cancers. © 2024 Elsevier Inc.
Keywords: unclassified drug; gene mutation; overall survival; genetics; missense mutation; clinical trial; drug efficacy; drug safety; note; antineoplastic agent; colorectal cancer; cd8+ t lymphocyte; tumor associated leukocyte; gene overexpression; progression free survival; phase 2 clinical trial; gene expression; antineoplastic combined chemotherapy protocols; drug effect; pathology; colorectal neoplasms; antigen presentation; immunology; acetylsalicylic acid; celecoxib; colorectal tumor; mismatch repair; cyclooxygenase 2; prostaglandin e2; upregulation; genetic disorder; tumor growth; drug therapy; major histocompatibility complex; programmed death 1 receptor; tumor microenvironment; metastatic colorectal cancer; gamma delta t lymphocyte; prostaglandin synthase inhibitor; immune checkpoint inhibitor; cyclooxygenase inhibitors; humans; human; rna sequencing; pembrolizumab; programmed cell death 1 receptor; immune checkpoint inhibitors; mismatch repair deficient; anti pd 1; bat 1306
Journal Title: Med
Volume: 5
Issue: 8
ISSN: 2666-6359
Publisher: Cell Press  
Date Published: 2024-08-09
Start Page: 839
End Page: 841
Language: English
DOI: 10.1016/j.medj.2024.06.009
PUBMED: 39127029
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85200394127&doi=10.1016%2fj.medj.2024.06.009&partnerID=40&md5=817dcc38badb99bb3a7cd58f20b84eeb
Notes: Note -- Source: Scopus
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MSK Authors
  1. Benoit Rousseau
    50 Rousseau
  2. Paul Medalia Johannet
    9 Johannet
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