Intratumoral T-cell repertoires in DNA mismatch repair-proficient and -deficient colon tumors containing high or low numbers of tumor-infiltrating lymphocytes Journal Article
| Authors: | Kim, J. K.; Chen, C. T.; Keshinro, A.; Khan, A.; Firat, C.; Vanderbilt, C.; Segal, N.; Stadler, Z.; Shia, J.; Balachandran, V. P.; Weiser, M. R. |
| Article Title: | Intratumoral T-cell repertoires in DNA mismatch repair-proficient and -deficient colon tumors containing high or low numbers of tumor-infiltrating lymphocytes |
| Abstract: | Colon tumors with deficient DNA mismatch repair (dMMR) are generally infiltrated by T cells more densely than tumors with proficient mismatch repair (pMMR). However, high numbers of tumor-infiltrating lymphocytes (TILs) are found in select pMMR tumors, and low numbers of TILs are seen in select dMMR tumors. In this study, we compared T-cell repertoires in 20 pMMR and 27 dMMR colon tumors with high and low TIL counts. We found that T cells in dMMR tumors are more clonal and their repertoire is less rich compared with T cells in pMMR tumors. In the dMMR group, T cells in TIL-high tumors were more clonal and their repertoire was less rich compared with T cells in TIL-low tumors, but in the pMMR group, T-cell diversity in TIL-high tumors was comparable to T-cell diversity in TIL-low tumors. These findings suggest that T cells clonally expand in dMMR tumors, possibly in response to MMR deficiency-induced tumor neoantigens. © 2022 The Author(s). Published with license by Taylor & Francis Group, LLC. |
| Keywords: | colon cancer; mismatch repair deficiency; t-cell repertoire; tumor-infiltrating-lymphocytes; tumor mutational burden |
| Journal Title: | OncoImmunology |
| Volume: | 11 |
| Issue: | 1 |
| ISSN: | 2162-4011 |
| Publisher: | Landes Bioscience |
| Date Published: | 2022-01-01 |
| Start Page: | e2054757 |
| Language: | English |
| DOI: | 10.1080/2162402x.2022.2054757 |
| PROVIDER: | scopus |
| PMCID: | PMC9037499 |
| PUBMED: | 35481287 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 May 2022 -- Source: Scopus |
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