Long-term outcome of peripheral T-cell lymphomas: Ten-year follow-up of the International Prospective T-cell Project Journal Article
| Authors: | Civallero, M.; Schroers-Martin, J. G.; Horwitz, S.; Manni, M.; Stepanishyna, Y.; Cabrera, M. E.; Vose, J.; Spina, M.; Hitz, F.; Nagler, A.; Montoto, S.; Chiattone, C.; Skrypets, T.; Perez Saenz, M. A.; Priolo, G.; Luminari, S.; Lymboussaki, A.; Pavlovsky, A.; Marino, D.; Liberati, M.; Trotman, J.; Mannina, D.; Federico, M.; Advani, R. |
| Article Title: | Long-term outcome of peripheral T-cell lymphomas: Ten-year follow-up of the International Prospective T-cell Project |
| Abstract: | Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of haematological cancers with generally poor clinical outcomes. However, a subset of patients experience durable disease control, and little is known regarding long-term outcomes. The International T-cell Lymphoma Project (ITCLP) is the largest prospectively collected cohort of patients with PTCLs, providing insight into clinical outcomes at academic medical centres globally. We performed a long-term outcome analysis on patients from the ITCLP with available 10-year follow-up data (n = 735). The overall response rate to first-line therapy was 68%, while 5- and 10-year overall survival estimates were 49% and 40% respectively. Most deaths occurred prior to 5 years, and for patients alive at 5 years, the chance of surviving to 10 years was 84%. However, lymphoma remained the leading cause of death in the 5- to 10-year period (67%). Low-risk International Prognostic Index and Prognostic Index for T-cell lymphoma scores both identified patients with improved survival, while in multivariate analysis, age >60 years and Eastern Cooperative Oncology Group performance status 2–4 were associated with inferior outcomes. The favourable survival seen in patients achieving durable initial disease control emphasizes the unmet need for optimal front-line therapeutic approaches in PTCLs. © 2024 British Society for Haematology and John Wiley & Sons Ltd. |
| Keywords: | adolescent; adult; human tissue; treatment outcome; aged; aged, 80 and over; middle aged; young adult; major clinical study; overall survival; clinical trial; mortality; follow up; follow-up studies; prospective study; prospective studies; progression free survival; etoposide; cohort analysis; hemoglobin; autologous stem cell transplantation; risk factor; peripheral t cell lymphoma; albumin; multicenter study; asparaginase; outcome; lactate dehydrogenase; multivariate analysis; drug therapy; anthracycline; therapy; platelet count; follow-up; international prognostic index; lymphoma, t-cell, peripheral; clinical outcome; overall response rate; very elderly; humans; prognosis; human; male; female; article; t-cell lymphomas; ecog performance status; tcp1 |
| Journal Title: | British Journal of Haematology |
| Volume: | 205 |
| Issue: | 1 |
| ISSN: | 0007-1048 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2024-07-01 |
| Start Page: | 166 |
| End Page: | 174 |
| Language: | English |
| DOI: | 10.1111/bjh.19433 |
| PUBMED: | 38532575 |
| PROVIDER: | scopus |
| PMCID: | PMC11931637 |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
