International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis Review
| Authors: | Chen, X.; Tsvetkov, A. S.; Shen, H. M.; Isidoro, C.; Ktistakis, N. T.; Linkermann, A.; Koopman, W. J. H.; Simon, H. U.; Galluzzi, L.; Luo, S.; Xu, D.; Gu, W.; Peulen, O.; Cai, Q.; Rubinsztein, D. C.; Chi, J. T.; Zhang, D. D.; Li, C.; Toyokuni, S.; Liu, J.; Roh, J. L.; Dai, E.; Juhasz, G.; Liu, W.; Zhang, J.; Yang, M.; Liu, J.; Zhu, L. Q.; Zou, W.; Piacentini, M.; Ding, W. X.; Yue, Z.; Xie, Y.; Petersen, M.; Gewirtz, D. A.; Mandell, M. A.; Chu, C. T.; Sinha, D.; Eftekharpour, E.; Zhivotovsky, B.; Besteiro, S.; Gabrilovich, D. I.; Kim, D. H.; Kagan, V. E.; Bayir, H.; Chen, G. C.; Ayton, S.; Lünemann, J. D.; Komatsu, M.; Krautwald, S.; Loos, B.; Baehrecke, E. H.; Wang, J.; Lane, J. D.; Sadoshima, J.; Yang, W. S.; Gao, M.; Münz, C.; Thumm, M.; Kampmann, M.; Yu, D.; Lipinski, M. M.; Jones, J. W.; Jiang, X.; Zeh, H. J.; Kang, R.; Klionsky, D. J.; Kroemer, G.; Tang, D. |
| Review Title: | International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis |
| Abstract: | Macroautophagy/autophagy is a complex degradation process with a dual role in cell death that is influenced by the cell types that are involved and the stressors they are exposed to. Ferroptosis is an iron-dependent oxidative form of cell death characterized by unrestricted lipid peroxidation in the context of heterogeneous and plastic mechanisms. Recent studies have shed light on the involvement of specific types of autophagy (e.g. ferritinophagy, lipophagy, and clockophagy) in initiating or executing ferroptotic cell death through the selective degradation of anti-injury proteins or organelles. Conversely, other forms of selective autophagy (e.g. reticulophagy and lysophagy) enhance the cellular defense against ferroptotic damage. Dysregulated autophagy-dependent ferroptosis has implications for a diverse range of pathological conditions. This review aims to present an updated definition of autophagy-dependent ferroptosis, discuss influential substrates and receptors, outline experimental methods, and propose guidelines for interpreting the results. Abbreviation: 3-MA:3-methyladenine; 4HNE: 4-hydroxynonenal; ACD: accidentalcell death; ADF: autophagy-dependentferroptosis; ARE: antioxidant response element; BH2:dihydrobiopterin; BH4: tetrahydrobiopterin; BMDMs: bonemarrow-derived macrophages; CMA: chaperone-mediated autophagy; CQ:chloroquine; DAMPs: danger/damage-associated molecular patterns; EMT,epithelial-mesenchymal transition; EPR: electronparamagnetic resonance; ER, endoplasmic reticulum; FRET: Försterresonance energy transfer; GFP: green fluorescent protein;GSH: glutathione;IF: immunofluorescence; IHC: immunohistochemistry; IOP, intraocularpressure; IRI: ischemia-reperfusion injury; LAA: linoleamide alkyne;MDA: malondialdehyde; PGSK: Phen GreenTM SK;RCD: regulatedcell death; PUFAs: polyunsaturated fatty acids; RFP: red fluorescentprotein;ROS: reactive oxygen species; TBA: thiobarbituricacid; TBARS: thiobarbituric acid reactive substances; TEM:transmission electron microscopy. © 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. |
| Keywords: | immunohistochemistry; review; nonhuman; mass spectrometry; animal; animals; cell death; cell viability; gene; consensus; gene expression; nuclear protein; protein metabolism; heart disease; kidney disease; fluorescent dye; lipid; transcription factor; practice guideline; genetic transcription; phosphorylation; assay; cancer therapy; physiology; carcinogenesis; hypoxia; acute kidney failure; membrane protein; iron; brain disease; liver disease; innate immunity; upregulation; asthma; osteoporosis; eye disease; glaucoma; autophagy; mitochondrial protein; lipid peroxidation; spectroscopy; ultrastructure; mitochondrion; cell organelle; glutathione; cysteine; acyltransferase; periodontal disease; pancreas disease; knockout mouse; bone disease; lysosome; respiratory tract disease; macromolecule; mitochondrial dna; lysosome membrane; iron transport; ferric ion; macroautophagy; degradation; reperfusion injury; transmission electron microscopy; adaptor protein; fat droplet; escrt protein; circadian rhythm; fatty acid transport; periodontitis; autophagosome; electron spin resonance; beclin 1; liver fibrosis; lipid storage; cystine; iron storage; 4 hydroxynonenal; cell nucleus dna; polyunsaturated fatty acid; chaperone-mediated autophagy; peroxidation; hippocalcin; ferroptosis; autophagic cell death; kelch like ech associated protein 1; mitophagy; humans; human; 3 methyladenine; ferroportin; membrane damage; genetically engineered mouse strain; selective autophagy; ferritinophagy; heat shock cognate protein 70; malignant neoplasm; autophagy (cellular); phospholipid hydroperoxide glutathione peroxidase; microautophagy; lysophagy; reticulophagy; lipophagy; sapropterin; thiobarbituric acid reactive substance; clockophagy; lipophagocytosis |
| Journal Title: | Autophagy |
| Volume: | 20 |
| Issue: | 6 |
| ISSN: | 1554-8627 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2024-01-01 |
| Start Page: | 1213 |
| End Page: | 1246 |
| Language: | English |
| DOI: | 10.1080/15548627.2024.2319901 |
| PUBMED: | 38442890 |
| PROVIDER: | scopus |
| PMCID: | PMC11210914 |
| DOI/URL: | |
| Notes: | Review -- Source: Scopus |
