Management of metastatic pheochromocytomas and paragangliomas: When and what Review
| Authors: | Sukrithan, V.; Perez, K.; Pandit-Taskar, N.; Jimenez, C. |
| Review Title: | Management of metastatic pheochromocytomas and paragangliomas: When and what |
| Abstract: | Recently, the treatment landscape for metastatic pheochromocytomas and paragangliomas (MPPGL) has seen both progress and setbacks. We provide an up-to-date review of the multimodality management of MPPGL and discuss novel opportunities and current challenges in the treatment landscape. Given the unique clinical presentation of MPPGL, we discuss the management of hormone-related clinical sequelae and traditional modalities of therapy. Advances in the understanding of the molecular biology of these diverse tumors have enabled novel strategies such as augmenting DNA damage by targeted delivery of radionuclides such as 131I and 177Lu, abrogating tumor angiogenesis, hypoxia resistance, and DNA damage repair. Despite progress, we address the significant challenges still faced by patients and researchers engaged in efforts to improve outcomes in these rare cancers. © 2024 The Authors |
| Keywords: | cancer chemotherapy; cancer surgery; clinical feature; nonhuman; systemic therapy; temozolomide; medical decision making; dna damage; dna repair; paraganglioma; cancer immunotherapy; metastasis; genetic variability; angiogenesis; cancer resistance; protein tyrosine kinase inhibitor; germ line; cancer vaccine; cardiovascular disease; diabetes mellitus; hypoglycemia; (3 iodobenzyl)guanidine i 131; mammalian target of rapamycin inhibitor; pheochromocytoma; gastrointestinal disease; catecholamine; radioisotope therapy; tumor hypoxia; olaparib; molecularly targeted therapy; alpha radiation; gamma radiation; cabozantinib; human; article; prrt; lutathera; belzutifan; azedra; capecitabine/temozolomide; cvd; i-131 iobenguane; metastatic pheochromocytoma and paraganglioma |
| Journal Title: | Current Problems in Cancer |
| Volume: | 51 |
| ISSN: | 0147-0272 |
| Publisher: | Mosby Elsevier |
| Date Published: | 2024-08-01 |
| Start Page: | 101116 |
| Language: | English |
| DOI: | 10.1016/j.currproblcancer.2024.101116 |
| PROVIDER: | scopus |
| PUBMED: | 39024846 |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
