Redefining the standard of care for low-grade serous ovarian cancer Review
| Authors: | Manning-Geist, B. L.; Cantor, T.; O'Cearbhaill, R. E.; Grisham, R. N. |
| Review Title: | Redefining the standard of care for low-grade serous ovarian cancer |
| Abstract: | Low-grade serous carcinoma is a rare epithelial ovarian cancer subtype with distinct clinical, histologic, and molecular features. Improved understanding of this disease subtype has prompted recent advances in treatment options. Although low-grade serous carcinoma historically has been treated following a high-grade serous carcinoma paradigm, new data have called into question the utility of platinum retreatment, addressed the possibility of first-line hormonal treatment, and brought forth therapeutic options targeting the MAPK pathway and cyclin D kinase in low-grade tumors. Ongoing research efforts seek to leverage the unique features of low-grade serous carcinoma to refine treatment options for patients with this rare tumor subtype. |
| Keywords: | cancer grading; ovarian neoplasms; pathology; health care quality; ovary tumor; diagnosis; ovary carcinoma; cystadenocarcinoma, serous; drug therapy; therapy; cystadenocarcinoma; molecularly targeted therapy; standard of care; molecular targeted therapy; neoplasm grading; humans; human; female; carcinoma, ovarian epithelial |
| Journal Title: | Clinical Advances in Hematology & Oncology |
| Volume: | 22 |
| Issue: | 5 |
| ISSN: | 1543-0790 |
| Publisher: | Millennium Medical Publishing, Inc |
| Date Published: | 2024-06-01 |
| Start Page: | 205 |
| End Page: | 226 |
| Language: | English |
| PUBMED: | 38805312 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF -- Corresponding authors is MSK author: Rachel N. Grisham -- Source: Scopus |
