Low-grade serous neoplasms of the ovary with transformation to high-grade carcinomas: A report of 3 cases Journal Article
| Authors: | Garg, K.; Park, K. J.; Soslow, R. A. |
| Article Title: | Low-grade serous neoplasms of the ovary with transformation to high-grade carcinomas: A report of 3 cases |
| Abstract: | Ovarian borderline tumors usually occur in young patients and are associated with good clinical outcomes. A proportion of these tumors, particularly those with micropapillary features, may progress to low-grade serous carcinomas. Evolution of low-grade serous neoplasms to high-grade carcinomas is rare and infrequently reported. In this case report, we describe 3 cases of serous borderline tumor that progressed to high-grade carcinoma. Patient ages were 22, 35, and 47yr. Two patients were initially diagnosed with ovarian serous borderline tumor, and recurred in the pelvis 3 and 10 yr later with sarcomatoid carcinoma. The third patient presented with low-grade serous carcinoma arising in a micropapillary serous borderline tumor, and recurred with a carcinosarcoma 3 yr later. All 3 patients had an aggressive clinical course: 2 died of disease and 1 patient has disease progression on chemotherapy. Occasional low-grade serous tumors of the ovary may transform to high-grade carcinomas, which can occur many years after initial diagnosis. The presence of a high-grade component significantly worsens patient outcomes. © 2012 International Society of Gynecological Pathologists. |
| Keywords: | adult; human tissue; middle aged; mutation; case report; bevacizumab; doxorubicin; cancer combination chemotherapy; cancer growth; paclitaxel; cancer radiotherapy; recurrent cancer; cancer grading; ovarian neoplasms; cancer mortality; cell transformation, neoplastic; ovary; ovary carcinoma; tumor suppressor protein p53; sarcomatoid carcinoma; cystadenocarcinoma, serous; pelvis cancer; genes, p53; carcinosarcoma; fatality; low-grade serous carcinoma; neoplasm grading; serous borderline tumor; progression to high-grade carcinoma |
| Journal Title: | International Journal of Gynecological Pathology |
| Volume: | 31 |
| Issue: | 5 |
| ISSN: | 0277-1691 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2012-09-01 |
| Start Page: | 423 |
| End Page: | 428 |
| Language: | English |
| DOI: | 10.1097/PGP.0b013e31824ae6f2 |
| PROVIDER: | scopus |
| PUBMED: | 22833081 |
| PMCID: | PMC4849135 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 4 September 2012" - "CODEN: IJGPD" - "Source: Scopus" |
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