Low-grade serous neoplasms of the ovary with transformation to high-grade carcinomas: A report of 3 cases Journal Article


Authors: Garg, K.; Park, K. J.; Soslow, R. A.
Article Title: Low-grade serous neoplasms of the ovary with transformation to high-grade carcinomas: A report of 3 cases
Abstract: Ovarian borderline tumors usually occur in young patients and are associated with good clinical outcomes. A proportion of these tumors, particularly those with micropapillary features, may progress to low-grade serous carcinomas. Evolution of low-grade serous neoplasms to high-grade carcinomas is rare and infrequently reported. In this case report, we describe 3 cases of serous borderline tumor that progressed to high-grade carcinoma. Patient ages were 22, 35, and 47yr. Two patients were initially diagnosed with ovarian serous borderline tumor, and recurred in the pelvis 3 and 10 yr later with sarcomatoid carcinoma. The third patient presented with low-grade serous carcinoma arising in a micropapillary serous borderline tumor, and recurred with a carcinosarcoma 3 yr later. All 3 patients had an aggressive clinical course: 2 died of disease and 1 patient has disease progression on chemotherapy. Occasional low-grade serous tumors of the ovary may transform to high-grade carcinomas, which can occur many years after initial diagnosis. The presence of a high-grade component significantly worsens patient outcomes. © 2012 International Society of Gynecological Pathologists.
Keywords: adult; human tissue; middle aged; mutation; case report; bevacizumab; doxorubicin; cancer combination chemotherapy; cancer growth; paclitaxel; cancer radiotherapy; recurrent cancer; cancer grading; ovarian neoplasms; cancer mortality; cell transformation, neoplastic; ovary; ovary carcinoma; tumor suppressor protein p53; sarcomatoid carcinoma; cystadenocarcinoma, serous; pelvis cancer; genes, p53; carcinosarcoma; fatality; low-grade serous carcinoma; neoplasm grading; serous borderline tumor; progression to high-grade carcinoma
Journal Title: International Journal of Gynecological Pathology
Volume: 31
Issue: 5
ISSN: 0277-1691
Publisher: Lippincott Williams & Wilkins  
Date Published: 2012-09-01
Start Page: 423
End Page: 428
Language: English
DOI: 10.1097/PGP.0b013e31824ae6f2
PROVIDER: scopus
PUBMED: 22833081
PMCID: PMC4849135
DOI/URL:
Notes: --- - "Export Date: 4 September 2012" - "CODEN: IJGPD" - "Source: Scopus"
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
  1. Kay Jung Park
    308 Park
  2. Robert Soslow
    797 Soslow
  3. Karuna Garg
    76 Garg