Abstract: |
Radiopharmaceutical therapy broadly refers to the administration of a compound that emits ionizing radiation for the purpose of cancer treatment. Today, this often assumes the form of a radionuclide that (a) exhibits inherent tropism for a specific lesion or (b) is conjugated to a pharmaceutical carrier that confers target specificity. This elegant approach draws from diverse scientific disciplines that can be traced through history. The history of radiopharmaceutical therapy progressed via multiple, independent streams, and the instances at which these streams collide are inflection points that allowed new ideas and technologies to flourish. In this review, we summarize the seminal discoveries and the people behind them that set the stage for the modern field of radiopharmaceutical therapy. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2023. |