Magnetic resonance relaxometry in quantitative imaging of brain gliomas: A literature review Review
| Authors: | Chekhonin, I. V.; Cohen, O.; Otazo, R.; Young, R. J.; Holodny, A. I.; Pronin, I. N. |
| Review Title: | Magnetic resonance relaxometry in quantitative imaging of brain gliomas: A literature review |
| Abstract: | Magnetic resonance (MR) relaxometry is a quantitative imaging method that measures tissue relaxation properties. This review discusses the state of the art of clinical proton MR relaxometry for glial brain tumors. Current MR relaxometry technology also includes MR fingerprinting and synthetic MRI, which solve the inefficiencies and challenges of earlier techniques. Despite mixed results regarding its capability for brain tumor differential diagnosis, there is growing evidence that MR relaxometry can differentiate between gliomas and metastases and between glioma grades. Studies of the peritumoral zones have demonstrated their heterogeneity and possible directions of tumor infiltration. In addition, relaxometry offers T2* mapping that can define areas of tissue hypoxia not discriminated by perfusion assessment. Studies of tumor therapy response have demonstrated an association between survival and progression terms and dynamics of native and contrast-enhanced tumor relaxometric profiles. In conclusion, MR relaxometry is a promising technique for glial tumor diagnosis, particularly in association with neuropathological studies and other imaging techniques. © The Author(s) 2023. |
| Keywords: | vasculotropin; review; neuroimaging; nuclear magnetic resonance imaging; positron emission tomography; brain tumor; glioma; brain neoplasms; magnetic resonance imaging; diagnostic accuracy; sensitivity and specificity; diagnostic procedure; metastasis; progression free survival; cell infiltration; diagnosis, differential; differential diagnosis; recurrence; tumor regression; pathology; diagnostic imaging; angiogenesis; cancer therapy; hypoxia; tumor recurrence; glioblastoma; angiogenesis inhibitors; oxygen consumption; tumor diagnosis; neuropathology; infiltration; procedures; electron spin resonance; humans; human; fluid-attenuated inversion recovery imaging; magnetic resonance relaxometry; quantitative phase imaging |
| Journal Title: | The Neuroradiology Journal |
| Volume: | 37 |
| Issue: | 3 |
| ISSN: | 1971-4009 |
| Publisher: | Sage Publications Ltd. |
| Date Published: | 2024-06-01 |
| Start Page: | 267 |
| End Page: | 275 |
| Language: | English |
| DOI: | 10.1177/19714009231173100 |
| PUBMED: | 37133228 |
| PROVIDER: | scopus |
| PMCID: | PMC11138331 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PubMed record and PDF -- Source: Scopus |
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