Childbirth rates in women with myeloproliferative neoplasms Journal Article
| Authors: | Landtblom, A. R.; Andersson, T. M. L.; Johansson, A. L. V.; Lundberg, F. E.; Samuelsson, J.; Björkholm, M.; Hultcrantz, M. |
| Article Title: | Childbirth rates in women with myeloproliferative neoplasms |
| Abstract: | Myeloproliferative neoplasms (MPN) are associated with inferior pregnancy outcome, however, little is known about fertility and childbearing potential in women with MPN. In this study we aimed to describe reproductive patterns, as well as to quantify risk of miscarriage and stillbirth. Women aged 15–44 years with an MPN diagnosis 1973–2018, were identified in Swedish health care registers, and age-matched 1:4 to population controls. We identified 1141 women with MPN and 4564 controls. Women with MPN had a lower rate of childbirth (hazard ratio [HR] with 95% confidence interval was 0.78 (0.68–0.90)). Subgroup analysis showed that the rate was not significantly reduced in essential thrombocythemia, HR 1.02 (0.86–1.22) while the HR was 0.50 (0.33–0.76) in PV and 0.45 (0.28–0.74) in PMF. The risk of miscarriage was not significantly increased before MPN diagnosis, the HR during follow-up after diagnosis was 1.25 (0.89-1.76). Women with MPN were more likely to have had a previous stillbirth. Women with MPN had fewer children at diagnosis, and fewer children in total. In conclusion, the childbirth rate was lower among women with MPN than controls, but not among women with essential thrombocythemia. © The Author(s) 2024. |
| Keywords: | adolescent; adult; controlled study; myeloproliferative disorders; young adult; major clinical study; case control study; myeloproliferative disorder; case-control studies; follow up; follow-up studies; prospective study; sensitivity analysis; disease association; quality of life; risk factors; risk factor; sweden; health care; hospitalization; register; registries; pregnancy; hazard ratio; myeloproliferative neoplasm; female fertility; thrombocythemia; pregnancy outcome; reproductive health; complication; spontaneous abortion; birth rate; stillbirth; childbirth; humans; human; female; article; abortion, spontaneous; fetus wastage |
| Journal Title: | Leukemia |
| Volume: | 38 |
| Issue: | 5 |
| ISSN: | 0887-6924 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2024-05-01 |
| Start Page: | 1081 |
| End Page: | 1085 |
| Language: | English |
| DOI: | 10.1038/s41375-024-02216-8 |
| PUBMED: | 38461191 |
| PROVIDER: | scopus |
| PMCID: | PMC11073981 |
| DOI/URL: | |
| Notes: | Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PubMed and PDF -- Source: Scopus |
