Pregnancy and childbirth outcomes in women with myeloproliferative neoplasms—a nationwide population-based study of 342 pregnancies in Sweden Journal Article
| Authors: | Landtblom, A. R.; Andersson, T. M. L.; Johansson, A. L. V.; Wendel, S. B.; Lundberg, F. E.; Samuelsson, J.; Björkholm, M.; Hultcrantz, M. |
| Article Title: | Pregnancy and childbirth outcomes in women with myeloproliferative neoplasms—a nationwide population-based study of 342 pregnancies in Sweden |
| Abstract: | Pregnancy and childbirth in women with myeloproliferative neoplasms (MPN) are reported to be associated with maternal thrombosis, hemorrhage, and placental dysfunction. To assess the risks of adverse events in pregnancy in women with MPN, we performed a large population-based study using Swedish health care registers, and included all pregnancies that had reached gestational week 22 (prior to 2008, week 28) during the years 1973–2017 in women with MPN. Control pregnancies were matched 1:1 for age, calendar year, and parity. We identified 342 pregnancies in 229 women with MPN. Preterm birth was significantly increased in pregnancies in MPN, 14% compared to 4% of pregnancies in controls (p < 0.001). Correspondingly, low birth weight (<2500 g) was also significantly increased in MPN pregnancies (p = 0.042). Stillbirth was rare, with two events (0.6%) in MPN, none in controls. Maternal thrombotic complications occurred in three (1%) of the pregnancies in MPN patients, compared to none in controls. Pregnancy-related bleeding affected 14% of pregnancies in MPN and 9% in controls (p < 0.110). Cesarean section was significantly more common in pregnancies in MPN. Incidence was 12.2 per 100.000 pregnancies. In summary, preterm birth was an important complication in MPN pregnancies, while maternal complications were less common than previously reported. © 2022, The Author(s). |
| Keywords: | adult; controlled study; myeloproliferative disorders; major clinical study; myeloproliferative disorder; neoplasm; neoplasms; bleeding; incidence; morbidity; prevalence; cohort analysis; age; sweden; infant, newborn; gestational age; thrombosis; newborn; pregnancy; low birth weight; prematurity; myeloproliferative neoplasm; placenta; cesarean section; pregnancy outcome; population based case control study; preeclampsia; premature labor; spontaneous abortion; parity; pregnant woman; stillbirth; childbirth; newborn morbidity; newborn mortality; apgar score; high risk pregnancy; humans; human; female; article; birth weight; maternal disease; obstetric delivery; calendar year; perinatal outcome; premature birth |
| Journal Title: | Leukemia |
| Volume: | 36 |
| Issue: | 10 |
| ISSN: | 0887-6924 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2022-10-01 |
| Start Page: | 2461 |
| End Page: | 2467 |
| Language: | English |
| DOI: | 10.1038/s41375-022-01688-w |
| PUBMED: | 36071101 |
| PROVIDER: | scopus |
| PMCID: | PMC9522578 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 November 2022 -- Source: Scopus |
