Comparison between pelvic MRI, CT, and PET/CT in baseline staging and radiation planning of anal squamous cell carcinoma Journal Article
| Authors: | Horvat, N.; Jayaprakasam, V. S.; Crane, C. H.; Zheng, J.; Gangai, N.; Romesser, P. B.; Golia Pernicka, J. S.; Capanu, M.; Gollub, M. J. |
| Article Title: | Comparison between pelvic MRI, CT, and PET/CT in baseline staging and radiation planning of anal squamous cell carcinoma |
| Abstract: | Purpose: To investigate the differences in baseline staging of anal squamous cell carcinoma based on CT, MRI, and PET/CT, and the resultant impact on the radiation plan. Methods: This retrospective study included consecutive patients with anal squamous cell carcinoma who underwent baseline pelvic MRI, CT, and PET/CT (all examinations within 3 weeks of each other) from January 2010 to April 2020. CTs, MRIs, and PET/CTs were re-interpreted by three separate radiologists. Several imaging features were assessed; tumor stage was determined based on the eight edition of the American Joint Committee on Cancer (AJCC) staging manual; and T (tumor), N (node), and M (metastasis) categories were determined based on National Comprehensive Cancer Network (NCCN) guidelines. Radiologist assessments were then randomly presented to a radiation oncologist who formulated the radiation plan in a blinded fashion. Results: Across 28 patients (median age, 62 years [range, 31–78], T-category classification was significantly different on PET/CT compared to MRI and CT (p = 0.037 and 0.031, respectively). PET/CT staged a higher proportion of patients with T1/T2 disease (16/28, 57%) compared to MRI (11/28, 39%) and CT (10/28, 36%). MRI staged a higher proportion of patients with T3/T4 disease (14/28, 50%) compared to CT (12/28, 43%) and PET/CT (11/28, 39%). However, there was no significant difference between the three imaging modalities in terms of either N-category, AJCC staging, or NCCN TNM group classification, or in treatment planning. Conclusion: Our exploratory study showed that MRI demonstrated a higher proportion of T3/T4 tumors, while PET/CT demonstrated more T1/T2 tumors; however, MRI, CT, and PET/CT did not show any significant differences in AJCC and TNM group categories, nor was there any significant difference in treatment doses between them when assessed independently by an experienced radiation oncologist. Graphical abstract: (Figure presented.) © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. |
| Keywords: | adult; aged; middle aged; retrospective studies; squamous cell carcinoma; carcinoma, squamous cell; comparative study; cancer staging; nuclear magnetic resonance imaging; positron emission tomography; magnetic resonance imaging; neoplasm staging; radiotherapy; tomography, x-ray computed; pathology; diagnostic imaging; retrospective study; radiotherapy planning, computer-assisted; computed tomography; anal cancer; anus neoplasms; anus tumor; procedures; humans; human; male; female; radiotherapy planning system; x-ray computed tomography; positron emission tomography-computed tomography; positron emission tomography computed tomography |
| Journal Title: | Abdominal Radiology |
| Volume: | 49 |
| Issue: | 5 |
| ISSN: | 2366-004X |
| Publisher: | Springer |
| Date Published: | 2024-05-01 |
| Start Page: | 1351 |
| End Page: | 1362 |
| Language: | English |
| DOI: | 10.1007/s00261-024-04213-y |
| PUBMED: | 38456896 |
| PROVIDER: | scopus |
| PMCID: | PMC11613965 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF -- Corresponding author is MSK author: Marc J. Gollub -- Source: Scopus |
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