Targeting the kidneys at the nanoscale: Nanotechnology in nephrology Review


Authors: Vasylaki, A.; Ghosh, P.; Jaimes, E. A.; Williams, R. M.
Review Title: Targeting the kidneys at the nanoscale: Nanotechnology in nephrology
Abstract: Kidney diseases, both acute and chronic, are a substantial burden on individual and public health, and they continue to increase in frequency. Despite this and an intense focus on the study of disease mechanisms, few new therapeutic approaches have extended to the clinic. This is in part due to poor pharmacology of many, if not most, therapeutics with respect to the sites of kidney disease within the glomerulus or nephron. Considering this, within the past decade, and more pointedly over the past 2 years, there have been substantial developments in nanoparticle systems to deliver therapeutics to the sites of kidney disease. Here, we provide a broad overview of the various classes of nanomaterials that have been developed to improve therapeutic development for kidney diseases, the strategy used to provide kidney accumulation, and briefly the disease models they focused on, if any. We then focus on one specific system, polymeric mesoscale nanoparticles, which has broadly been used over 13 publications, demonstrating targeting of the tubular epithelium with 26-fold specificity compared with other organs. While there have been several nanomedicines that have advanced to the clinic in the past several decades, including mRNA-based coronavirus disease vaccines and others, none have focused on kidney diseases specifically. In total, we are confident that the rapid advancement of nanoscale-based kidney targeting and a concerted focus by clinicians, scientists, engineers, and other stakeholders will push one or more of these technologies into clinical trials over the next decade. © 2024 Lippincott Williams and Wilkins. All rights reserved.
Keywords: animal; metabolism; animals; kidney disease; drug effect; pathology; drug delivery systems; chemistry; kidney; nephrology; gene therapy; nanoparticles; nanomedicine; nanoparticle; drug delivery system; nanocarrier; pharmacokinetics; nanotechnology; proximal tubule; procedures; kidney diseases; glomerulus; humans; human; aki; ckd; nanoparticle drug delivery system
Journal Title: Kidney360
Volume: 5
Issue: 4
ISSN: 2641-7650
Publisher: Wolters Kluwer Health, Inc  
Date Published: 2024-04-01
Start Page: 618
End Page: 630
Language: English
DOI: 10.34067/kid.0000000000000400
PUBMED: 38414130
PROVIDER: scopus
PMCID: PMC11093552
DOI/URL:
Notes: Review -- Source: Scopus
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
  1. Edgar Alberto Jaimes
    81 Jaimes
Related MSK Work