Ultrasmall renally clearable silica nanoparticles target prostate cancer Journal Article

   


Authors: Chen, F.; Ma, K.; Zhang, L.; Madajewski, B.; Turker, M. Z.; Gallazzi, F.; Cruickshank, K.; Zhang, X.; Jenjitranant, P.; Touijer, K. A.; Quinn, T. P.; Zanzonico, P.; Wiesner, U.; Bradbury, M. S.
Article Title: Ultrasmall renally clearable silica nanoparticles target prostate cancer
Abstract: Although important advances have been achieved in the development of radiolabeled prostate-specific membrane antigen (PSMA)-targeting ligand constructs for both diagnosis and therapy of prostate cancer (PCa) over the past decade, challenges related to off-target effects and limited treatment responses persist. In this study, which builds upon the successful clinical translation of a series of ultrasmall, dye-encapsulating core-shell silica nanoparticles, or Cornell Prime Dots (C′ dots), for cancer management, we sought to address these limitations by designing a dual-modality, PSMA-targeting platform that evades undesirable accumulations in the salivary glands, kidneys, and reticuloendothelial system, while exhibiting bulk renal clearance. This versatile PCa-targeted particle imaging probe offers significant clinical potential to improve future theranostic applications in a variety of patient care settings. © 2019 American Chemical Society.
Keywords: prostate cancer; urology; nanoparticles; silica; prostate cancers; diseases; clinical translation; psma; targeting; calcium compounds; prostate-specific membrane antigens; silica nanoparticles; core-shell silica nanoparticles; c′ dots; reticuloendothelial systems; ultrasmall; ultra-small
Journal Title: ACS Applied Materials & Interfaces
Volume: 11
Issue: 47
ISSN: 1944-8244
Publisher: American Chemical Society  
Date Published: 2019-11-27
Start Page: 43879
End Page: 43887
Language: English
DOI: 10.1021/acsami.9b15195
PUBMED: 31675204
PROVIDER: scopus
PMCID: PMC7199444
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85075055221&doi=10.1021%2facsami.9b15195&partnerID=40&md5=98efe1fe23d969feed1ba117775b44a2
Notes: Source: Scopus
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Karim Abdelkrim Touijer
    259 Touijer
  2. Michelle S Bradbury
    65 Bradbury
  3. Pat B Zanzonico
    357 Zanzonico
  4. Li Zhang
    15 Zhang
  5. Feng Chen
    18 Chen
  6. Brian Madajewski
    12 Madajewski
  7. Kiara L Cruickshank
    2 Cruickshank
  8. Pocharapong Jenjitranant
    3 Jenjitranant
Related MSK Work