MIRD pamphlet no. 29: MIRDy90-A (90)Y research microsphere dosimetry tool Journal Article

   


Authors: Marquis, H.; Ocampo Ramos, J. C.; Carter, L. M.; Zanzonico, P.; Bolch, W. E.; Laforest, R.; Kesner, A. L.
Article Title: MIRD pamphlet no. 29: MIRDy90-A (90)Y research microsphere dosimetry tool
Abstract: 90Y-microsphere radioembolization has become a well-established treatment option for liver malignancies and is one of the first U.S. Food and Drug Administration-approved unsealed radionuclide brachytherapy devices to incorporate dosimetry-based treatment planning. Several different mathematical models are used to calculate the patient-specific prescribed activity of 90Y, namely, body surface area (SIR-Spheres only), MIRD single compartment, and MIRD dual compartment (partition). Under the auspices of the MIRDsoft initiative to develop community dosimetry software and tools, the body surface area, MIRD single-compartment, MIRD dual-compartment, and MIRD multicompartment models have been integrated into a MIRDy90 software worksheet. The worksheet was built in MS Excel to estimate and compare prescribed activities calculated via these respective models. The MIRDy90 software was validated against available tools for calculating 90Y prescribed activity. The results of MIRDy90 calculations were compared with those obtained from vendor and communitydeveloped tools, and the calculations agreed well. The MIRDy90 worksheet was developed to provide a vetted tool to better evaluate patient-specific prescribed activities calculated via different models, as well as model influences with respect to varying input parameters. MIRDy90 allows users to interact and visualize the results of various parameter combinations. Variables, equations, and calculations are described in the MIRDy90 documentation and articulated in the MIRDy90 worksheet. The worksheet is distributed as a free tool to build expertise within the medical physics community and create a vetted standard for model and variable management. © 2024 by the Society of Nuclear Medicine andMolecular Imaging.
Keywords: dosimetry; physical activity; mathematical computing; body surface; process development; microsphere; yttrium 90; radioembolization; process design; physical parameters; human; article; 90y-microspheres; mird dual-compartment dosimetry; partition model dosimetry; selective internal radiation therapy (sirt)
Journal Title: Journal of Nuclear Medicine
Volume: 65
Issue: 5
ISSN: 0161-5505
Publisher: Society of Nuclear Medicine  
Date Published: 2024-05-01
Start Page: 794
End Page: 802
Language: English
DOI: 10.2967/jnumed.123.266743
PUBMED: 38388514
PROVIDER: scopus
PMCID: PMC11064830
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85193012610&doi=10.2967%2fjnumed.123.266743&partnerID=40&md5=99f9d0872afa75b831ea90046fadbfac
Notes: The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF. Corresponding MSK author is Adam L. Kesner -- Source: Scopus
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MSK Authors
  1. Pat B Zanzonico
    355 Zanzonico
  2. Adam Leon Kesner
    68 Kesner
  3. Lukas M Carter
    79 Carter
  4. Juan Camilo Ocampo Ramos
    27 Ocampo Ramos
  5. Harry Marquis
    17 Marquis
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