When it's not ovarian cancer: A case of a massive leiomyoma with hydropic change Journal Article


Authors: Erfani, H.; Chiang, S.; Dickinson, S.; Chi, D. S.; Kim, S. H.
Article Title: When it's not ovarian cancer: A case of a massive leiomyoma with hydropic change
Abstract: Background: Uterine leiomyomas are benign tumors characterized by pelvic pain and abnormal bleeding. Their evolution can lead to degenerative changes, occasionally mimicking malignancies on imaging, presenting diagnostic challenges. Case presentation: A 31-year-old nulliparous woman presented with symptoms of bloating, cramping, and abdominal distension. Imaging suggested an advanced ovarian malignancy, showing a complex adnexal mass and elevated CA-125 levels. During exploratory laparotomy, what was suspected to be ovarian cancer was instead identified as a large uterine mass on pathologic evaluation revealing a benign leiomyoma with extensive hydropic change. Conclusion: This case highlights the diagnostic intricacies associated with large complex adnexal masses and illustrates how benign conditions like leiomyomas with hydropic degeneration can mimic ovarian cancer. This emphasizes the importance of comprehensive preoperative and intraoperative assessments to tailor management and avoid unindicated radical procedures. © 2024
Keywords: adult; clinical article; human tissue; histopathology; case report; ascites; laparotomy; ovarian cancer; computer assisted tomography; tumor volume; tumor biopsy; ca 125 antigen; ca-125; frozen section; uterus myoma; abdominal cramp; cancer morphology; liver injury; satiety; abdominal radiography; endometriosis; abdominal distension; abdominal discomfort; fertility preservation; bloating; transvaginal echography; nullipara; pelvis radiography; skin incision; degeneration; adnexal mass; human; female; article; diagnostic challenges; lesion volume; uterine leiomyoma; antigen blood level; abnormal value; hydropic degeneration; tissue adhesion; unilateral salpingooophorectomy; uterine adnexa
Journal Title: Gynecologic Oncology Reports
Volume: 53
ISSN: 2352-5789
Publisher: Elsevier B.V.  
Date Published: 2024-05-31
Start Page: 101415
Language: English
DOI: 10.1016/j.gore.2024.101415
PROVIDER: scopus
PMCID: PMC11126525
PUBMED: 38798949
DOI/URL:
Notes: Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PDF -- MSK corresponding author is Sarah Kim -- Source: Scopus
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MSK Authors
  1. Dennis S Chi
    707 Chi
  2. Sarah   Chiang
    146 Chiang
  3. Sarah H Kim
    43 Kim
  4. Hadi Erfani
    1 Erfani