Somatic mutations in surgically treated colorectal liver metastases: An overview Review
| Authors: | Wang, J.; Botvinov, J.; Bhatt, A. J.; Beyer, K.; Kreis, M. E.; Adam, M.; Alseidi, A.; Margonis, G. A. |
| Review Title: | Somatic mutations in surgically treated colorectal liver metastases: An overview |
| Abstract: | Colorectal cancer is the second most common cause of cancer death in the United States, and up to half of patients develop colorectal liver metastases (CRLMs). Notably, somatic genetic mutations, such as mutations in RAS, BRAF, mismatch repair (MMR) genes, TP53, and SMAD4, have been shown to play a prognostic role in patients with CRLM. This review summarizes and appraises the current literature regarding the most relevant somatic mutations in surgically treated CRLM by not only reviewing representative studies, but also providing recommendations for areas of future research. In addition, advancements in genetic testing and an increasing emphasis on precision medicine have led to a more nuanced understanding of these mutations; thus, more granular data for each mutation are reviewed when available. Importantly, such knowledge can pave the way for precision medicine with the ultimate goal of improving patient outcomes. © 2024 by the authors. |
| Keywords: | cancer survival; treatment outcome; gene mutation; somatic mutation; genetics; mutation; review; liver neoplasms; chemotherapy; clinical practice; colorectal cancer; cell proliferation; gene; transforming growth factor beta; cell differentiation; pathology; protein p53; cancer therapy; colorectal neoplasms; colorectal tumor; mismatch repair; dna mismatch repair; liver tumor; cell cycle arrest; recurrent disease; hepatectomy; cancer epidemiology; genetic screening; b raf kinase; braf; ras; mlh1 gene; cell stress; personalized medicine; surgical margin; smad4 protein; somatic mutations; machine learning; msh2 gene; cancer prognosis; mapk signaling; colorectal liver metastasis; humans; human; precision medicine; mutl protein homolog 1; dna mismatch repair protein msh2; tgf beta signaling; crlm; pms1 gene |
| Journal Title: | Cells |
| Volume: | 13 |
| Issue: | 8 |
| ISSN: | 2073-4409 |
| Publisher: | MDPI |
| Date Published: | 2024-04-02 |
| Start Page: | 679 |
| Language: | English |
| DOI: | 10.3390/cells13080679 |
| PUBMED: | 38667294 |
| PROVIDER: | scopus |
| PMCID: | PMC11049420 |
| DOI/URL: | |
| Notes: | Review -- Source: Scopus |
