Hepatic resection, hepatic arterial infusion pump therapy, and genetic biomarkers in the management of hepatic metastases from colorectal cancer Journal Article
| Authors: | McAuliffe, J. C.; Qadan, M.; D'Angelica, M. I. |
| Article Title: | Hepatic resection, hepatic arterial infusion pump therapy, and genetic biomarkers in the management of hepatic metastases from colorectal cancer |
| Abstract: | The liver is the most common site of colorectal cancer metastasis. Fortunately, improvements have been made in the care of patients with colorectal liver metastasis (CRLM). Effective management of crlm requires a multidisciplinary approach that is tailored to individuals in order to achieve long-term survival, and cure. resection and systemic chemotherapy provides benefit in selected individuals. An adjunct to resection and/or systemic chemotherapy is the use of hepatic arterial infusion pump (HAIP) therapy. Many studies show HAIP provides benefit for select patients with CRLM. Added to the crucible of a multidisciplinary approach to managing CRLM is the ever growing understanding of tumor biology and genetic profiling. In this review, we discuss the outcomes of resection, systemic therapies and haip therapy for CRLM. We also discuss the impact of recent advances in genetic profiling and mutational analysis, namely mutation of KRAS and BRAF, for this disease. © Journal of Gastrointestinal Oncology. All rights reserved. |
| Keywords: | gene mutation; overall survival; drug tolerability; review; cancer recurrence; bevacizumab; fluorouracil; cancer risk; drug efficacy; drug safety; follow up; interleukin 2; progression free survival; tumor volume; dexamethasone; retrospective study; cetuximab; irinotecan; folinic acid; liver resection; disease free interval; resection; kras; oncogene k ras; mitomycin; oxaliplatin; floxuridine; b raf kinase; disease specific survival; braf; computed tomographic angiography; braf gene; recurrence free survival; randomized controlled trial (topic); meta analysis (topic); phase 3 clinical trial (topic); infusion pump; folfox; metastasis resection; colorectal liver metastasis; human; hepatic arterial infusion pump; colorectal liver metastasis (crlm); parenchymal-sparing; hepatic artery infusion pump (haip) |
| Journal Title: | Journal of Gastrointestinal Oncology |
| Volume: | 6 |
| Issue: | 6 |
| ISSN: | 2078-6891 |
| Publisher: | Pioneer Bioscience Publishing Company |
| Date Published: | 2015-12-01 |
| Start Page: | 699 |
| End Page: | 708 |
| Language: | English |
| DOI: | 10.3978/j.issn.2078-6891.2015.081 |
| PROVIDER: | scopus |
| PMCID: | PMC4671858 |
| PUBMED: | 26697204 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 6 December 2016 -- Source: Scopus |
