Points to consider regarding prophylactic total gastrectomy in germline CDH1 variant carriers Review
| Authors: | Corso, G.; Davis, J. L.; Strong, V. E. |
| Review Title: | Points to consider regarding prophylactic total gastrectomy in germline CDH1 variant carriers |
| Abstract: | Pathogenic germline CDH1 mutation confers high risk for developing diffuse gastric and lobular breast cancers in asymptomatic carriers. In these individuals, the estimated gastric cancer risk at 80 years of age is up to 70% for males and 56% for females. Due to this high-risk predisposition, prophylactic total gastrectomy is considered a unique life-saving approach in germline CDH1 carriers, as endoscopy often fails to detect early stage diffuse gastric carcinoma. However, surgical indication is controversial in some clinical contexts, with possible contraindications. This review discusses points against and in favor of a more aggressive surgical approach for consideration during the decision-making process. © 2024 The Authors. Journal of Surgical Oncology published by Wiley Periodicals LLC. |
| Keywords: | genetics; genetic predisposition to disease; gastrectomy; antigens, cd; genetic predisposition; cadherin; cadherins; stomach neoplasms; leukocyte antigen; germ-line mutation; stomach tumor; gastric cancer; germline mutation; procedures; cdh1 protein, human; prophylactic total gastrectomy; humans; human; female; prophylactic surgical procedure; cdh1 germline mutation; prophylactic surgical procedures |
| Journal Title: | Journal of Surgical Oncology |
| Volume: | 129 |
| Issue: | 6 |
| ISSN: | 0022-4790 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2024-05-01 |
| Start Page: | 1082 |
| End Page: | 1088 |
| Language: | English |
| DOI: | 10.1002/jso.27603 |
| PUBMED: | 38389278 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Source: Scopus |
