NTRK-rearranged spindle cell neoplasm: Initial observation of imaging appearance and clinicopathologic correlation Journal Article
| Authors: | Spano, M.; Davis-Hayes, C.; Hameed, M.; Benayed, R.; Hwang, S. |
| Article Title: | NTRK-rearranged spindle cell neoplasm: Initial observation of imaging appearance and clinicopathologic correlation |
| Abstract: | Objective: To explore pre-treatment imaging findings of neurotrophic tyrosine receptor kinase (NTRK)-rearranged spindle cell neoplasm, an emerging group of molecularly defined soft tissue tumors and summarize the clinical course, including TRK inhibitor therapy response. Materials and methods: This retrospective study included 8 women and 4 men with NTRK-rearranged spindle cell neoplasm (median age, 35.5 years, range, 0–66). Available pre-treatment MRI, CT, PET, and US imaging were reviewed. Tumor histology and the patients' clinical course were reviewed. Results: Primary tumors were located within the soft tissue, lungs, kidney, and breast with soft tissue being the most prevalent site (n = 6). Pre-treatment MRI (n = 4) revealed linear hypointense signal foci and contrast enhancement in all patients with hemorrhage in half of the tumors. A tail sign (n = 1) and fluid levels (n = 1) were less frequent. Ultrasound showed well-marginated hypoechoic masses with internal flow. Primary tumors were all non-calcified on CT (4/4). Metastases were FDG-avid (4/4). Among the 8 patients who developed metastasis, 7 developed pulmonary metastases. All four patients who received NTRK inhibitor therapy showed an initial decrease in tumor size or FDG uptake. Conclusion: NTRK-rearranged neoplasms may occur as enhancing masses with linear hypointense signal foci on MRI and FDG avid metastases on PET. Pulmonary metastases were frequent in our study. Initial treatment response is observed in most patients. © 2024 Elsevier Inc. |
| Keywords: | adolescent; adult; child; clinical article; human tissue; preschool child; treatment response; aged; middle aged; young adult; disease course; nuclear magnetic resonance imaging; positron emission tomography; magnetic resonance imaging; gene; tumor localization; computer assisted tomography; tumor volume; prevalence; pathology; retrospective study; histology; ultrasound; soft tissue; lung tumor; cancer inhibition; lung metastasis; gene rearrangement; kidney tumor; infant; computerized tomography; tumors; contrast enhancement; breast tumor; echography; newborn; fluorodeoxyglucose f 18; soft tissue sarcoma; imaging; age distribution; amino acids; patient treatment; spindle cell carcinoma; pet; ct; tumor bleeding; soft tissue tumor; neurotrophic; ultrasonics; clinical course; pulmonary metastasis; mr; human; male; female; article; ntrk; receptor kinase; neurotrophic tyrosine receptor kinase; pre-treatments; neurotrophic tyrosine receptor kinase gene |
| Journal Title: | Clinical Imaging |
| Volume: | 110 |
| ISSN: | 0899-7071 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2024-05-31 |
| Start Page: | 110134 |
| Language: | English |
| DOI: | 10.1016/j.clinimag.2024.110134 |
| PROVIDER: | scopus |
| PUBMED: | 38631176 |
| PMCID: | PMC11586688 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF -- Corresponding author is MSK author: Matthew Spano -- Source: Scopus |
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