Nutrient uptake strategies shift during mouse epiblast development Editorial
| Authors: | Todorova, P. K.; Finley, L. W. S. |
| Title: | Nutrient uptake strategies shift during mouse epiblast development |
| Abstract: | Murine blastocysts and embryonic stem cells mimicking the pre-implantation epiblast import extracellular protein through macropinocytosis and engage a robust lysosomal digestive programme to meet their nutrient demands. We found that as development proceeds, post-implantation epiblast-like cells downregulate protein digestion, increase expression of amino acid transporters and become dependent on soluble amino acids. |
| Journal Title: | Nature Metabolism |
| Volume: | 6 |
| Issue: | 1 |
| ISSN: | 2522-5812 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2024-01-01 |
| Start Page: | 16 |
| End Page: | 17 |
| Language: | English |
| ACCESSION: | WOS:001135839200002 |
| DOI: | 10.1038/s42255-023-00941-5 |
| PROVIDER: | wos |
| PUBMED: | 38172383 |
| Notes: | Article -- Source: Wos |
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