Pathologic features, treatment, and clinical outcomes of lacrimal gland cancer Journal Article


Authors: Karp, J. M.; Gordon, A. J.; Hu, K.; Belinsky, I.; Jacobson, A.; Li, Z. J.; Persky, M.; Persky, M.; Givi, B.; Tam, M. M.
Article Title: Pathologic features, treatment, and clinical outcomes of lacrimal gland cancer
Abstract: Objectives: Lacrimal gland cancer is a rare malignancy with little data known about its pathologic characteristics or optimal management. We performed a large database analysis using the National Cancer Database (NCDB) to elucidate this unusual condition. Methods: Patients with lacrimal gland cancer diagnosed between 2004 and 2018 were included in the analysis. Using available clinical data, we excluded all patients with histologies likely reflective of lacrimal sac or duct cancer, which are coded similarly to lacrimal gland cancer in the NCDB. Kaplan -Meier analysis was used to estimate overall survival (OS), and Cox proportional hazards models were used to indicate covariates associated with survival. Results: A total of 440 cases of lacrimal gland cancer were included in the analysis, with a median follow-up of 52.9 months. The five-year OS for the entire cohort was 65.0%. Adenoid cystic carcinoma was the predominant histology (47.3%). Cox models showed that improved OS was associated with surgical resection (UVA: p < 0.001; MVA: p = 0.035). A detriment in OS was associated with increasing age, Charlson-Deyo score of 1, T4 stage, and positive margins and on UVA for adenocarcinoma and malignant mixed tumor histology. Conclusion: Adenoid cystic carcinoma comprises the plurality of lacrimal gland cancers. About half of patients with lacrimal gland carcinoma will live beyond 10 years, underscoring the importance of reduced morbidity of treatment. Surgical management is associated with improved prognosis. Further study will elucidate the role of surgical excision and radiotherapy in lacrimal gland cancer.
Keywords: chemotherapy; tumors; carcinoma; adenoid cystic carcinoma; epidemiology; management; lacrimal gland; lacrimal sac; lacrimal duct; lacrimal gland cancer
Journal Title: Cureus
Volume: 15
Issue: 8
ISSN: 2168-8184
Publisher: Cureus Inc.  
Date Published: 2023-08-01
Start Page: e44466
Language: English
ACCESSION: WOS:001168179900033
DOI: 10.7759/cureus.44466
PROVIDER: wos
PMCID: PMC10544231
PUBMED: 37791145
Notes: Source: Wos
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  1. Babak Givi
    24 Givi