Extra-abdominal cytoreductive techniques in ovarian cancer: How far can (should) we go? Review
| Authors: | Kahn, R. M.; Chang, S. J.; Chi, D. S. |
| Review Title: | Extra-abdominal cytoreductive techniques in ovarian cancer: How far can (should) we go? |
| Abstract: | Complex surgery is an essential component in the management of advanced ovarian cancer. Furthermore, achieving complete gross resection in cytoreductive surgery appears to be associated with significant survival benefits in patients with advanced ovarian cancer. The goal of this review is to demonstrate the advancement of surgical techniques in gynecologic oncology surgery, including resection of disease within the intrathoracic and inguinal regions. This progress has expanded the option of surgery to more patients, especially those who would have previously been deemed inoperable. In this review we describe the most notable studies and reports of surgical resection of ovarian cancer involving cardiophrenic/supradiaphragmatic lymph nodes, mediastinum, lung pleura or parenchyma, and the inguinal region. We also describe the growing role that video-assisted thoracic surgery has played in advanced ovarian cancer diagnosis and management. The studies, series, and reports described demonstrate that comprehensive surgical procedures outside of the abdomen or pelvis can be both safe and feasible in properly selected patients. They also suggest that resection of disease outside of the abdomen or pelvis may benefit appropriately selected patients. Future studies are necessary to identify which patients may benefit most from upfront surgery versus neoadjuvant chemotherapy when ovarian cancer metastasis is present in the thoracic or inguinal regions. © IGCS and ESGO 2024. No commercial re-use. See rights and permissions. Published by BMJ. |
| Keywords: | cancer surgery; review; advanced cancer; lymph node metastasis; antineoplastic agent; cancer diagnosis; lymph node dissection; pelvis; ovarian cancer; cytoreductive surgery; ovarian neoplasms; ovary cancer; abdomen; lymph node; ovary tumor; ovary carcinoma; gynecologic surgical procedures; inguinal lymph node; neoadjuvant chemotherapy; mediastinum; pleura; video assisted thoracoscopic surgery; mediastinum metastasis; inguinal region; surgical oncology; humans; human; female; cytoreduction surgical procedures; carcinoma, ovarian epithelial |
| Journal Title: | International Journal of Gynecological Cancer |
| Volume: | 34 |
| Issue: | 3 |
| ISSN: | 1048-891X |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2024-03-01 |
| Start Page: | 379 |
| End Page: | 385 |
| Language: | English |
| DOI: | 10.1136/ijgc-2023-004630 |
| PUBMED: | 38438179 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PDF -- MSK corresponding author is Dennis Chi -- Source: Scopus |
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