Spitz melanocytic tumors: A fascinating 75-year journey Review
| Authors: | Chatzopoulos, K.; Syrnioti, A.; Linos, K. |
| Review Title: | Spitz melanocytic tumors: A fascinating 75-year journey |
| Abstract: | Over the last 75 years, our understanding of Spitz lesions has undergone substantial evolution. Initially considered a specific type of melanoma, the perception has shifted towards recognizing Spitz lesions as a spectrum comprising Spitz nevi, Spitz melanocytomas, and Spitz melanomas. Spitz lesions are known for posing a significant diagnostic challenge regarding the distinction between benign neoplasms displaying atypical traits and melanomas. A comprehensive understanding of their molecular basis and genomic aberrations has significantly improved precision in classifying and diagnosing these challenging lesions. The primary aim of this review is to encapsulate the current understanding of the molecular pathogenesis and distinct clinicopathologic characteristics defining this intriguing set of tumors. © 2024 by the authors. |
| Keywords: | immunohistochemistry; clinical article; human tissue; single nucleotide polymorphism; genetics; mutation; review; case report; cancer growth; brain tumor; brain neoplasms; cell proliferation; cancer susceptibility; melanoma; nevus; skin neoplasms; pathology; morphology; patient care; skin tumor; syndrome; artificial intelligence; epithelium cell; genomics; spitz nevus; nevus, epithelioid and spindle cell; epidermis hyperplasia; molecular pathology; melanocytic; spitz; atypical spitz tumor; melanocytic tumor; humans; human; female; spitzoid; deep learning; atypical spitz nevus; spitz melanoma; spitzoid lesions; epithelioid melanocytic proliferation |
| Journal Title: | Genes |
| Volume: | 15 |
| Issue: | 2 |
| ISSN: | 2073-4425 |
| Publisher: | MDPI |
| Date Published: | 2024-02-02 |
| Start Page: | 195 |
| Language: | English |
| DOI: | 10.3390/genes15020195 |
| PUBMED: | 38397186 |
| PROVIDER: | scopus |
| PMCID: | PMC10887813 |
| DOI/URL: | |
| Notes: | Review -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PubMed and PDF, as P30 CA08748 -- MSK corresponding author is Konstantinos Linos -- Source: Scopus |
