Insights into how adeno-squamous transition drives KRAS inhibitor resistance Editorial
| Authors: | Hu, F.; Lito, P. |
| Title: | Insights into how adeno-squamous transition drives KRAS inhibitor resistance |
| Abstract: | The histologic transformation of adenocarcinoma (ADC) to squamous cell carcinoma (SCC), known as adeno-squamous transition or AST, is frequently observed in patients with lung cancer undergoing cancer therapy. In this issue, Tong and colleagues investigate genetic and epigenetic mechanisms that drive AST to confer resistance to KRAS inhibitors in preclinical models and patients. © 2024 |
| Keywords: | genetics; squamous cell carcinoma; carcinoma, squamous cell; nonhuman; treatment duration; note; adenocarcinoma; gene expression; lung neoplasms; pathology; histology; cancer resistance; lung tumor; epigenetics; oncogene k ras; k ras protein; malignant transformation; protein p21; proto-oncogene proteins p21(ras); kras protein, human; patent; ectopic expression; humans; human; rna sequencing; sotorasib; adagrasib |
| Journal Title: | Cancer Cell |
| Volume: | 42 |
| Issue: | 3 |
| ISSN: | 1535-6108 |
| Publisher: | Cell Press |
| Date Published: | 2024-03-11 |
| Start Page: | 330 |
| End Page: | 332 |
| Language: | English |
| DOI: | 10.1016/j.ccell.2024.02.014 |
| PUBMED: | 38471455 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF -- Corresponding author is MSK authors: Piro Lito -- Source: Scopus |
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