Prognosis and patterns of care in elderly patients with glioma Journal Article

Authors: Iwamoto, F. M.; Reiner, A. S.; Nayak, L.; Panageas, K. S.; Elkin, E. B.; Abrey, L. E.
Article Title: Prognosis and patterns of care in elderly patients with glioma
Abstract: BACKGROUND: The current study was conducted to evaluate the patterns of care and survival of older adults with oligodendroglioma (OLI) and astrocytoma (AST) from a large population-based registry. METHODS: The authors identified a cohort of OLI and AST patients aged ≥65 years from Surveillance, Epidemiology and End Results (SEER) cancer registry data linked with Medicare claims between 1994 and 2002. Patients with a diagnosis of glioblastoma were excluded. The impact of demographic characteristics and comorbidities on the probability of undergoing surgical resection, radiotherapy (RT), and chemotherapy within 6 months of diagnosis was assessed using multivariate logistic regression. RESULTS: A total of 1067 patients (891 with AST and 176 with OLI) were included; the median survival was 9 months for patients with low-grade AST, 4 months for patients with anaplastic AST, 57 months for patients with low-grade OLI, and 9 months for patients with anaplastic OLI. Approximately 54% of patients underwent resection at the time of diagnosis; 66% received RT, and 13% received chemotherapy within 6 months of diagnosis. In a multivariate regression analysis, age and tumor grade were found to be the most significant predictors of resection, RT, or chemotherapy. Patients with anaplastic tumors were treated with resection, RT, and chemotherapy more often than patients with low-grade tumors, and OLI patients received chemotherapy more frequently than AST. CONCLUSIONS: Data from the current study suggested that histologic diagnosis and tumor grade retained significant prognostic value in this elderly AST and OLI population. Furthermore, age and tumor grade were found to influence the probability of undergoing surgery, RT, and chemotherapy in this cohort. © 2009 American Cancer Society.
Keywords: cancer survival; aged; aged, 80 and over; survival analysis; major clinical study; cancer patient; chemotherapy; glioma; brain neoplasms; antineoplastic agent; cancer grading; radiotherapy; cohort analysis; age factors; age; patient care; comorbidity; cancer registry; oligodendroglioma; astrocytoma; elderly
Journal Title: Cancer
Volume: 115
Issue: 23
ISSN: 0008-543X
Publisher: Wiley Blackwell  
Date Published: 2009-01-12
Start Page: 5534
End Page: 5540
Language: English
DOI: 10.1002/cncr.24612
PUBMED: 19708033
PROVIDER: scopus
Notes: --- - "Cited By (since 1996): 1" - "Export Date: 30 November 2010" - "CODEN: CANCA" - "Source: Scopus"
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MSK Authors
  1. Anne S Reiner
    120 Reiner
  2. Fabio M Iwamoto
    36 Iwamoto
  3. Elena B Elkin
    149 Elkin
  4. Lauren E Abrey
    272 Abrey
  5. Katherine S Panageas
    327 Panageas