Directional microwave ablation in spine: Experimental assessment of computational modeling Journal Article


Authors: Pfannenstiel, A.; Avellar, H.; Hallman, C.; Plattner, B. L.; Highland, M. A.; Cornelis, F. H.; Beard, W. L.; Prakash, P.
Article Title: Directional microwave ablation in spine: Experimental assessment of computational modeling
Abstract: Background: Despite the theoretical advantages of treating metastatic bone disease with microwave ablation (MWA), there are few reports characterizing microwave absorption and bioheat transfer in bone. This report describes a computational modeling-based approach to simulate directional microwave ablation (dMWA) in spine, supported by ex vivo and pilot in vivo experiments in porcine vertebral bodies. Materials and methods: A 3D computational model of microwave ablation within porcine vertebral bodies was developed. Ex vivo porcine vertebra experiments using a dMWA applicator measured temperatures approximately 10.1 mm radially from the applicator in the direction of MW radiation (T1) and approximately 2.4 mm in the contra-lateral direction (T2). Histologic assessment of ablated ex vivo tissue was conducted and experimental results compared to simulations. Pilot in vivo experiments in porcine vertebral bodies assessed ablation zones histologically and with CT and MRI. Results: Experimental T1 and T2 temperatures were within 3–7% and 11–33% of simulated temperature values. Visible ablation zones, as indicated by grayed tissue, were smaller than those typical in other soft tissues. Posthumous MRI images of in vivo ablations showed hyperintensity. In vivo experiments illustrated the technical feasibility of creating directional microwave ablation zones in porcine vertebral body. Conclusion: Computational models and experimental studies illustrate the feasibility of controlled dMWA in bone tissue. © 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.
Keywords: controlled study; bone tumor; histopathology; nonhuman; nuclear magnetic resonance imaging; animals; animal tissue; animal experiment; information processing; histology; soft tissue; liver; pilot study; spine; ablation techniques; temperature; computer simulation; computer model; radiofrequency ablation; ex vivo study; therapy; swine; catheter ablation; microwave radiation; microwaves; vertebra; intramuscular drug administration; vertebra body; microwave ablation; thermal ablation; surface property; thermal conductivity; bone tissue; pharmaceutics; trabecular bone; electric conductivity; electromagnetic radiation; intervertebral disk; human; article; microwave thermotherapy; directional antenna; bone ablation; mri scanner; three dimensional finite element analysis; heat transfer; transverse process
Journal Title: International Journal of Hyperthermia
Volume: 41
Issue: 1
ISSN: 0265-6736
Publisher: Taylor & Francis Group  
Date Published: 2024-01-01
Start Page: 2313492
Language: English
DOI: 10.1080/02656736.2024.2313492
PUBMED: 38369302
PROVIDER: scopus
PMCID: PMC11357707
DOI/URL:
Notes: The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF -- Source: Scopus
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