When CDK4/6i meets GPX4i: Stop dividing to die iron hard Editorial

  


Authors: Liang, D.; Jiang, X.
Title: When CDK4/6i meets GPX4i: Stop dividing to die iron hard
Abstract: In this issue of Cell Chemical Biology, Rodencal et al.1 report that cell-cycle arrest by p53 stabilizers or CDK4/6 inhibitors (CDK4/6i) can lead to phospholipid remodeling and hence sensitize cancer cells to GPX4 inhibitor (GPX4i)-triggered ferroptosis. This study suggests a novel cancer therapeutic strategy combining CDK4/6i with GPX4i. © 2024 Elsevier Ltd
Keywords: protein kinase inhibitor; protein kinase inhibitors; iron; phospholipids; phospholipid; ferroptosis
Journal Title: Cell Chemical Biology
Volume: 31
Issue: 2
ISSN: 2451-9456
Publisher: Cell Press  
Date Published: 2024-02-15
Start Page: 187
End Page: 189
Language: English
DOI: 10.1016/j.chembiol.2024.01.006
PUBMED: 38364774
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85184586983&doi=10.1016%2fj.chembiol.2024.01.006&partnerID=40&md5=7aec1d7f509c3041432aab9931f2bc0a
Notes: Note -- Source: Scopus
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MSK Authors
  1. Xuejun Jiang
    121 Jiang
  2. Deguang Liang
    9 Liang
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